Tìm theo
Clenbuterol
Các tên gọi khác (8 ) :
  • (+-)-Clenbuterol
  • (±)-clenbuterol
  • 1-(4-Amino-3,5-dichloro-phenyl)-2-tert-butylamino-ethanol
  • 4-amino-3,5-Dichloro-alpha-(((1,1-dimethylethyl)amino)methyl)benzenemethanol
  • 4-amino-alpha-((Tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol
  • 4-amino-α-((tert-butylamino)methyl)-3,5-dichlorobenzyl alcohol
  • CLENBUTEROL
  • Clenbuterolum
sympathomimetics, bronchodilator agents, adrenergic beta agonists
Thuốc Gốc
Small Molecule
CAS: 37148-27-9
ATC: R03CC13, R03AC14
CTHH: C12H18Cl2N2O
PTK: 277.19
A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C12H18Cl2N2O
Phân tử khối
277.19
Monoisotopic mass
276.079618622
InChI
InChI=1S/C12H18Cl2N2O/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7/h4-5,10,16-17H,6,15H2,1-3H3
InChI Key
InChIKey=STJMRWALKKWQGH-UHFFFAOYSA-N
IUPAC Name
1-(4-amino-3,5-dichlorophenyl)-2-(tert-butylamino)ethan-1-ol
Traditional IUPAC Name
clenbuterol
SMILES
CC(C)(C)NCC(O)C1=CC(Cl)=C(N)C(Cl)=C1
Độ tan chảy
174-175.5
Độ hòa tan
1.12e-01 g/l
logP
2.33
logS
-3.4
pKa (strongest acidic)
14.06
pKa (Strongest Basic)
9.63
PSA
58.28 Å2
Refractivity
73.38 m3·mol-1
Polarizability
28.81 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Clenbuterol is a substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma. Although approved for use in some countries, as of fall, 2006, clenbuterol is not an ingredient of any therapeutic drug approved by the U.S. Food and Drug Administration.
Cơ Chế Tác Dụng : A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma. [PubChem] Clenbuterol is a Beta(2) agonist similar in some structural respects to salbutamol. Agonism of the beta(2) receptor stimulates adenylyl cyclase activity which ultimately leads to downstream effects of smooth muscle relaxation in the bronchioles.
Dược Động Học :
▧ Absorption :
89-98% orally
▧ Half Life :
36-39 hours
Chỉ Định : Used as a bronchodilator in the treatment of asthma patients.
Dữ Kiện Thương Mại
Nhà Sản Xuất
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01407
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2783
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508373
ChemSpider
http://www.chemspider.com/Chemical-Structure.2681.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=27958
PharmGKB
http://www.pharmgkb.org/drug/PA164745640
Wikipedia
http://en.wikipedia.org/wiki/Clenbuterol
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