Tìm theo
Cinitapride
Các tên gọi khác (1) :
  • Paxapride
Thuốc Gốc
Small Molecule
CAS: 66564-14-5
CTHH: C21H30N4O4
PTK: 402.4873
Cinitapride is a gastroprokinetic agent and antiulcer agent of the benzamide class which is marketed in Spain and Mexico. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H30N4O4
Phân tử khối
402.4873
Monoisotopic mass
402.226705468
InChI
InChI=1S/C21H30N4O4/c1-2-29-20-13-18(22)19(25(27)28)12-17(20)21(26)23-16-8-10-24(11-9-16)14-15-6-4-3-5-7-15/h3-4,12-13,15-16H,2,5-11,14,22H2,1H3,(H,23,26)
InChI Key
InChIKey=ZDLBNXXKDMLZMF-UHFFFAOYSA-N
IUPAC Name
4-amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide
Traditional IUPAC Name
4-amino-N-[1-(cyclohex-3-en-1-ylmethyl)piperidin-4-yl]-2-ethoxy-5-nitrobenzamide
SMILES
CCOC1=CC(N)=C(C=C1C(=O)NC1CCN(CC2CCC=CC2)CC1)[N+]([O-])=O
Độ hòa tan
1.41e-02 g/l
logP
2.79
logS
-4.5
pKa (strongest acidic)
13.89
pKa (Strongest Basic)
9.74
PSA
113.41 Å2
Refractivity
115.58 m3·mol-1
Polarizability
44.29 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
6
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Cơ Chế Tác Dụng : Cinitapride is a gastroprokinetic agent and antiulcer agent of the benzamide class which is marketed in Spain and Mexico. It acts as an agonist of the 5-HT1 and 5-HT4 receptors and as an antagonist of the 5-HT2 receptors. Cinitapride is a substituted benzamide with 5-HT receptor antagonist and agonist activity.
Dược Động Học :
▧ Absorption :
The absorption of cinitapride (12mg) following oral administration was rapid, with peak levels being achieved 2 h after dosing; absorption following intramuscular administration (4mg) was even more rapid, with peak levels (50% more that oral levels) being achieved 1 h after dosing.
▧ Half Life :
3-5 h during the first 8 h and a residual half-life greater than 15 h thereafter.
Độc Tính : The symptoms of overdose include drowsiness, confusion and extrapyramidal effects.
Chỉ Định : For the treatment of gastrointestinal disorders associated with motility disturbances such as gastroesophageal reflux disease, non-ulcer dyspepsia and delayed gastric emptying.
Tương Tác Thuốc :
  • Atropine Anticholinergic agents like atropine may reduce the action of cinitapride.
  • Digoxin Cinitapride can alter the absorption of digoxin as it simulates gastric emptying.
  • Digoxin Immune Fab (Ovine) Cinitapride can alter the absorption of digoxin as it simulates gastric emptying.
  • Methylscopolamine bromide Anticholinergic agents like methylscopolamine may reduce the action of cinitapride.
  • Scopolamine Anticholinergic agents like scopolamine may reduce the action of cinitapride.
Liều Lượng & Cách Dùng : Tablet - Oral - 1mg
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Blaston
  • Công ty :
    Sản phẩm biệt dược : Cinmove
  • Công ty :
    Sản phẩm biệt dược : Cintapro
  • Công ty :
    Sản phẩm biệt dược : Paxapride
  • Công ty :
    Sản phẩm biệt dược : Pemix
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08810
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07700
PharmGKB
http://www.pharmgkb.org/drug/PA165958427
Wikipedia
http://en.wikipedia.org/wiki/Cinitapride
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