Tìm theo
Cinchocaine
Các tên gọi khác (15 ) :
  • 2-Butoxy-N-(2-(diethylamino)ethyl)cinchoninamide
  • 2-Butoxy-N-(alpha-diethylaminoethyl)cinchoninamide
  • 2-Butoxy-N-(beta-diethylaminoethyl)cinchoninamide
  • 2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide
  • 2-Butoxy-quinoline-4-carboxylic acid (2-diethylamino-ethyl)-amide
  • 2-Butoxyquinoline-4-carboxylic acid diethylaminoethylamide
  • 2-N-Butoxy-N-(2-diethylaminoethyl)cinchoninamide
  • alpha-Butyloxycinchonic acid-gamma-diethylethylenediamine
  • alpha-Butyloxycinchoninic acid diethylethylenediamide
  • CINCHOCAINE
  • Cinchocainum
  • Cincocainio
  • Dibucaine
  • Dibucaine base
  • N-(2-(Diethylamino)ethyl)-2-butoxycinchoninamide
Thuốc gây mê
Thuốc Gốc
Small Molecule
CAS: 85-79-0
ATC: C05AD04, D04AB02, N01BB06, S02DA04, S01HA06
ĐG : Medisca Inc. , http://www.medisca.com
CTHH: C20H29N3O2
PTK: 343.4632
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H29N3O2
Phân tử khối
343.4632
Monoisotopic mass
343.225977187
InChI
InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24)
InChI Key
InChIKey=PUFQVTATUTYEAL-UHFFFAOYSA-N
IUPAC Name
2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
Traditional IUPAC Name
dibucaine
SMILES
CCCCOC1=NC2=CC=CC=C2C(=C1)C(=O)NCCN(CC)CC
Độ tan chảy
99-101 °C (HCl salt)
Độ hòa tan
42 mg/L (at 21 °C)
logP
4.40
logS
-3.7
pKa (strongest acidic)
14.57
pKa (Strongest Basic)
9.04
PSA
54.46 Å2
Refractivity
102.12 m3·mol-1
Polarizability
40.78 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
4
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
pKa
8.85
Dược Lực Học : Dibucaine is an amide-type local anesthetic, similar to lidocaine.
Cơ Chế Tác Dụng : A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006) Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions through sodium channel inhibition. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Dược Động Học :
▧ Absorption :
In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation.
▧ Metabolism :
Primarily hepatic.
Độc Tính : Subcutaneous LD50 in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
Chỉ Định : For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
Liều Lượng & Cách Dùng : Ointment - Rectal
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Cincain
  • Công ty :
    Sản phẩm biệt dược : Nupercainal
  • Công ty :
    Sản phẩm biệt dược : Nupercaine
  • Công ty :
    Sản phẩm biệt dược : Sovcaine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00527
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=3025
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506734
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07879
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00733
ChemSpider
http://www.chemspider.com/Chemical-Structure.2917.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017687
PharmGKB
http://www.pharmgkb.org/drug/PA449286
Wikipedia
http://en.wikipedia.org/wiki/Dibucaine
Drugs.com
http://www.drugs.com/cdi/dibucaine-ointment.html
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