Tìm theo
Cidofovir
Các tên gọi khác (14 ) :
  • ({[(S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
  • (S)-(3-(4-amino-2-Oxopyrimidin-1(2H)-yl)-1-hydroxypropan-2-yloxy)methylphosphonic acid
  • (S)-1-(3-Hydroxy-2-phosphonomethoxypropyl)cytosine
  • (S)-1-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine
  • (S)-1-[3-Hydroxy-2-(phosphonylmethoxy)propyl]cytosine
  • (S)-HPMPC
  • [(S)-2-(4-Amino-2-oxo-2H-pyrimidin-1-yl)-1-hydroxymethyl-ethoxymethyl]-phosphonic acid
  • [[(S)-2-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1-(hydroxymethyl)ethoxy]methyl]phosphonic acid
  • 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine
  • 1-[(S)-3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine
  • CDV
  • Cidofovir
  • Cidofovir anhydrous
  • Cidofovirum
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 113852-37-2
ATC: J05AB12
ĐG : Gilead Sciences Inc. , http://www.gilead.com
CTHH: C8H14N3O6P
PTK: 279.187
Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C8H14N3O6P
Phân tử khối
279.187
Monoisotopic mass
279.062021707
InChI
InChI=1S/C8H14N3O6P/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16)/t6-/m0/s1
InChI Key
InChIKey=VWFCHDSQECPREK-LURJTMIESA-N
IUPAC Name
({[(2S)-1-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methyl)phosphonic acid
Traditional IUPAC Name
{[(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxy}methylphosphonic acid
SMILES
NC1=NC(=O)N(C[C@@H](CO)OCP(O)(O)=O)C=C1
Độ tan chảy
480 °C
Độ hòa tan
=170 mg/mL at pH 6-8
logP
-3.9
logS
-1.4
pKa (strongest acidic)
1.19
pKa (Strongest Basic)
2.15
PSA
145.68 Å2
Refractivity
60.43 m3·mol-1
Polarizability
24.44 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
8
H Bond Donor Count
4
Physiological Charge
-1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Cidofovir is a new anti-viral drug. It is classified as a nucleotide analogue and is active against herpes cytomegalovirus (CMV) retinitis infection. Most adults are infected with CMV. Cidofovir suppresses cytomegalovirus (CMV) replication by selective inhibition of viral DNA synthesis.
Cơ Chế Tác Dụng : Cidofovir is an injectable antiviral medication for the treatment of cytomegalovirus (CMV) retinitis in patients with AIDS. It suppresses CMV replication by selective inhibition of viral DNA synthesis. [Wikipedia] Cidofovir acts through the selective inhibition of viral DNA polymerase.Biochemical data support selective inhibition of CMV DNA polymerase by cidofovir diphosphate, the active intracellular metabolite of cidofovir. Cidofovir diphosphate inhibits herpesvirus polymerases at concentrations that are 8- to 600-fold lower than those needed to inhibit human cellular DNA polymerase alpha, beta, and gamma(1,2,3). Incorporation of cidofovir into the growing viral DNA chain results in reductions in the rate of viral DNA synthesis.
Dược Động Học :
▧ Absorption :
100%
▧ Volume of Distribution :
* 537 ± 126 mL/kg [VISTIDE ADMINISTERED WITHOUT PROBENECID] * 410 ± 102 mL/kg [VISTIDE ADMINISTERED WITH PROBENECID]
▧ Protein binding :
6%
▧ Half Life :
2.4 to 3.2 hours
▧ Clearance :
* 179 +/- 23.1 mL/min/1.73 m2 [WITHOUT PROBENECID] * 148 +/- 38.8 mL/min/1.73 m2 [WITH PROBENECID]
Độc Tính : Kidney damage, fall in the number of white blood cells, decreased platelets
Chỉ Định : For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS)
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Gilead
    Sản phẩm biệt dược : Vistide
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00369
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=60613
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506054
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06909
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00273
ChemSpider
http://www.chemspider.com/Chemical-Structure.54636.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=31915
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/61958-0101-1
PharmGKB
http://www.pharmgkb.org/drug/PA448997
Wikipedia
http://en.wikipedia.org/wiki/Cidofovir
RxList
http://www.rxlist.com/cgi/generic2/cidofovir.htm
Drugs.com
http://www.drugs.com/cdi/cidofovir.html
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