Tìm theo
Chlorphenesin
Các tên gọi khác (9 ) :
  • 3-(4-Chlorophenoxy)-1,2-propanediol
  • 3-(P-Chlorophenoxy)-1,2-propanediol
  • 3-(P-Chlorophenoxy)propane-1,2-diol
  • Chlorphenesin
  • Chlorphénésine
  • Chlorphenesinum
  • Clorfenesina
  • Glycerol alpha-P-chlorophenyl ether
  • P-Chlorophenyl-alpha-glyceryl ether
muscle relaxants central
Thuốc Gốc
Small Molecule
CAS: 104-29-0
ATC: D01AE07
CTHH: C9H11ClO3
PTK: 202.635
A centrally acting muscle relaxant. Its mode of action is unknown. Chlorphenesin is not available in the United States.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H11ClO3
Phân tử khối
202.635
Monoisotopic mass
202.039671925
InChI
InChI=1S/C9H11ClO3/c10-7-1-3-9(4-2-7)13-6-8(12)5-11/h1-4,8,11-12H,5-6H2
InChI Key
InChIKey=MXOAEAUPQDYUQM-UHFFFAOYSA-N
IUPAC Name
3-(4-chlorophenoxy)propane-1,2-diol
Traditional IUPAC Name
chlorphenesin
SMILES
OCC(O)COC1=CC=C(Cl)C=C1
Độ tan chảy
86–92
Độ hòa tan
1E+004 mg/L
logP
1.2
logS
-1.3
pKa (strongest acidic)
13.62
pKa (Strongest Basic)
-3
PSA
49.69 Å2
Refractivity
49.58 m3·mol-1
Polarizability
20.1 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Chlorphenesin is a muscle relaxant. It blocks nerve impulses (or pain sensations) that are sent to the brain.
Cơ Chế Tác Dụng : A centrally acting muscle relaxant. Its mode of action is unknown. Chlorphenesin is not available in the United States. The mechanism of action of chlorphenesin is not well defined, and its effects are measured mainly by subjective responses. It is known that chlorphenesin acts in the central nervous system (CNS) rather than directly on skeletal muscle.
Dược Động Học :
▧ Absorption :
Rapid and complete.
▧ Metabolism :
Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite.
▧ Half Life :
2.3-5 hours
Độc Tính : Symptoms of a chlorphenesin overdose include drowsiness and nausea.
Chỉ Định : Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release.
Tương Tác Thuốc :
  • Triprolidine The CNS depressants, Triprolidine and Chlorphenesin, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Kolpicortin
  • Công ty : UpJohn
    Sản phẩm biệt dược : Maolate
  • Công ty :
    Sản phẩm biệt dược : Rinlaxer
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00856
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7697
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504714
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07928
ChemSpider
http://www.chemspider.com/Chemical-Structure.7411.html
PharmGKB
http://www.pharmgkb.org/drug/PA164784022
Drugs.com
http://www.drugs.com/mtm/chlorphenesin.html
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