Tìm theo
Chloroxine
Các tên gọi khác (8 ) :
  • 5,7-Dichlor-8-hydroxychinolin
  • 5,7-Dichloro-8-hydroxyquinoline
  • 5,7-Dichloro-8-oxyquinoline
  • 5,7-Dichloro-8-quinolinol
  • 5,7-Dichlorooxine
  • 5,7-Dichloroxine
  • Chlorquinol
  • CHQ
anti seborrheic agents
Thuốc Gốc
Small Molecule
CAS: 773-76-2
ĐG : Contract Pharm , http://www.contractpharma.com
CTHH: C9H5Cl2NO
PTK: 214.048
Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H5Cl2NO
Phân tử khối
214.048
Monoisotopic mass
212.974819201
InChI
InChI=1S/C9H5Cl2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChI Key
InChIKey=WDFKMLRRRCGAKS-UHFFFAOYSA-N
IUPAC Name
5,7-dichloroquinolin-8-ol
Traditional IUPAC Name
chloroxine
SMILES
OC1=C(Cl)C=C(Cl)C2=C1N=CC=C2
Độ tan chảy
179.5 °C
Độ hòa tan
1.38e-01 g/l
logP
3
logS
-3.2
pKa (strongest acidic)
6.95
pKa (Strongest Basic)
3.4
PSA
33.12 Å2
Refractivity
51.57 m3·mol-1
Polarizability
19.32 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : Chloroxine has an antibacterial action, inhibiting the growth of gram-positive as well as some gram-negative organisms. Also, chloroxine has shown some antifungal activity against certain dermatophytes and yeasts.
Cơ Chế Tác Dụng : Chloroxine is a synthetic antibacterial compound. Chloroxine is a compound used in some shampoos for the treatment of dandruff and seborrheic dermatitis of the scalp. Although the mechanism of action is not understood, chloroxine may slow down mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp. Chloroxine induces SOS-DNA repair in E. coli, so chloroxine may be genotoxic to bacteria.
Độc Tính : The toxicological properties of this material have not been investigated.
Chỉ Định : Used in the treatment of dandruff and mild to moderately severe seborrheic dermatitis of the scalp.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Capitrol
  • Công ty :
    Sản phẩm biệt dược : Endiaron
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01243
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2722
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508620
ChemSpider
http://www.chemspider.com/Chemical-Structure.2621.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0072-6850-04
PharmGKB
http://www.pharmgkb.org/drug/PA164754879
Drugs.com
http://www.drugs.com/cons/chloroxine-topical.html
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