Tìm theo
Chloropyramine
Các tên gọi khác (5 ) :
  • Chloropyramine
  • Chlorpyramine
  • Halopyramine
  • SID11112580
  • SID50100492
histamine h1 antagonists, histamine antagonists
Thuốc Gốc
Small Molecule
CAS: 59-32-5
ATC: D04AA09, R06AC03
CTHH: C16H20ClN3
PTK: 289.803
Chloropyramine is a first generation antihistamine drug approved in some Eastern European countries for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Related indications for clinical use include Quincke's edema, allergic reactions to insect bites, food and drug allergies, and anaphylactic shock.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H20ClN3
Phân tử khối
289.803
Monoisotopic mass
289.134575362
InChI
InChI=1S/C16H20ClN3/c1-19(2)11-12-20(16-5-3-4-10-18-16)13-14-6-8-15(17)9-7-14/h3-10H,11-13H2,1-2H3
InChI Key
InChIKey=ICKFFNBDFNZJSX-UHFFFAOYSA-N
IUPAC Name
N-[(4-chlorophenyl)methyl]-N-[2-(dimethylamino)ethyl]pyridin-2-amine
Traditional IUPAC Name
chloropyramine
SMILES
CN(C)CCN(CC1=CC=C(Cl)C=C1)C1=CC=CC=N1
Độ tan chảy
< 25 °C
Độ sôi
154.5 °C at 2.00E-01 mm Hg
Độ hòa tan
Insoluble
logP
3.81
logS
-2.8
pKa (Strongest Basic)
8.76
PSA
19.37 Å2
Refractivity
86.08 m3·mol-1
Polarizability
32.25 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Chloropyramine is known as a competitive reversible H1-receptor antagonist (also known as an H1 inverse agonist), meaning that it exerts its pharmacological action by competing with histamine for the H1 subtype histamine receptor. By blocking the effects of histamine, the drug inhibits the vasodilation, increased vascular permeability, and tissue edema associated with histamine release in the tissue. In addition, chloropyramine has some anticholinergic properties. Chloropyramine's anticholinergic properties and the fact that it can pass through the blood-brain barrier are linked to its clinical side effects: drowsiness, weakness, vertigo, fatigue, dryness in the mouth, constipation, and rarely - visual disturbances and increase of intraocular pressure.
Cơ Chế Tác Dụng : Chloropyramine is a first generation antihistamine drug approved in some Eastern European countries for the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions. Related indications for clinical use include Quincke's edema, allergic reactions to insect bites, food and drug allergies, and anaphylactic shock. Chloropyramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Độc Tính : Oral (LD50): Acute: 142 mg/kg [Rat]. 135 mg/kg [Mouse]. DUST (LC50): Acute: 209 mg/m 2 hours [Rat].
Chỉ Định : For the treatment of allergic conjunctivitis, allergic rhinitis, bronchial asthma, and other atopic (allergic) conditions.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Avapena
  • Công ty :
    Sản phẩm biệt dược : Suprastin
  • Công ty :
    Sản phẩm biệt dược : Synopen
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08800
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07195
ChemSpider
http://www.chemspider.com/Chemical-Structure.23628.html
PharmGKB
http://www.pharmgkb.org/drug/PA165958419
... loading
... loading