Tìm theo
Chloroprocaine
Các tên gọi khác (7 ) :
  • 2-Chloroprocaine
  • 4-amino-2-Chlorobenzoic acid 2-(diethylamino)ethyl ester
  • Chloroprocain
  • Chloroprocaine
  • Chloroprocainum
  • Chlorprocaine
  • Cloroprocaina
Thuốc gây mê
Thuốc Gốc
Small Molecule
CAS: 133-16-4
ĐG : APP Pharmaceuticals , http://www.apppharma.com
CTHH: C13H19ClN2O2
PTK: 270.755
Chloroprocaine hydrochloride is a local anesthetic given by injection during surgical procedures and labor and delivery. Chloroprocaine, like other local anesthetics, blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H19ClN2O2
Phân tử khối
270.755
Monoisotopic mass
270.113505569
InChI
InChI=1S/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
InChI Key
InChIKey=VDANGULDQQJODZ-UHFFFAOYSA-N
IUPAC Name
2-(diethylamino)ethyl 4-amino-2-chlorobenzoate
Traditional IUPAC Name
chloroprocaine
SMILES
CCN(CC)CCOC(=O)C1=C(Cl)C=C(N)C=C1
Độ tan chảy
173-174
Độ hòa tan
0.665 mg/mL
logP
2.86
logS
-2.3
pKa (Strongest Basic)
8.96
PSA
55.56 Å2
Refractivity
75.1 m3·mol-1
Polarizability
28.74 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
3
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Chloroprocaine is an anesthetic agent indicated for production of local or regional anesthesia, particularly for oral surgery. Chloroprocaine (like cocaine) has the advantage of constricting blood vessels which reduces bleeding, unlike other local anesthetics like lidocaine. Chloroprocaine is an ester anesthetic.
Cơ Chế Tác Dụng : Chloroprocaine hydrochloride is a local anesthetic given by injection during surgical procedures and labor and delivery. Chloroprocaine, like other local anesthetics, blocks the generation and the conduction of nerve impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse and by reducing the rate of rise of the action potential. Chloroprocaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. It is hypothesized that Chloroprocaine binds or antagonizes the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex.
Dược Động Học :
▧ Absorption :
The rate of systemic absorption of local anesthetic drugs is dependent upon the total dose and concentration of drug administered, the route of administration, the vascularity of the administration site, and the presence or absence of epinephrine in the anesthetic injection.
▧ Metabolism :
Chloroprocaine is rapidly metabolized in plasma by hydrolysis of the ester linkage by pseudocholinesterase.
▧ Route of Elimination :
Chloroprocaine is rapidly metabolized in plasma by hydrolysis of the ester linkage by pseudocholinesterase. Urinary excretion is affected by urinary perfusion and factors affecting urinary pH.
▧ Half Life :
21 +/- 2 seconds
Độc Tính : In mice, the intravenous LD50 of chloroprocaine HCl is 97 mg/kg and the subcutaneous LD50 of chloroprocaine HCl is 950 mg/kg.
Chỉ Định : For the production of local anesthesia by infiltration and peripheral nerve block. They are not to be used for lumbar or caudal epidural anesthesia.
Liều Lượng & Cách Dùng : Injection, solution - Intravenous
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Nesacaine-mpf 2% vial
    Giá bán buôn : USD >1.28
    Đơn vị tính : ml
  • Biệt dược thương mại : Nesacaine-mpf 3% vial
    Giá bán buôn : USD >1.34
    Đơn vị tính : ml
  • Biệt dược thương mại : Chloroprocaine 2% vial
    Giá bán buôn : USD >0.26
    Đơn vị tính : ml
  • Biệt dược thương mại : Chloroprocaine 3% vial
    Giá bán buôn : USD >0.33
    Đơn vị tính : ml
  • Biệt dược thương mại : Nesacaine 1% vial
    Giá bán buôn : USD >0.72
    Đơn vị tính : ml
  • Biệt dược thương mại : Nesacaine 2% vial
    Giá bán buôn : USD >0.74
    Đơn vị tính : ml
Nhà Sản Xuất
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Nesacaine
  • Công ty : AstraZeneca
    Sản phẩm biệt dược : Nesacaine-CE
  • Công ty :
    Sản phẩm biệt dược : Piocaine
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01161
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=8612
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508245
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00732
ChemSpider
http://www.chemspider.com/Chemical-Structure.8293.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0409-4169-01
PharmGKB
http://www.pharmgkb.org/drug/PA448946
Wikipedia
http://en.wikipedia.org/wiki/Chloroprocaine
RxList
http://www.rxlist.com/cgi/generic3/chloroprocaine.htm
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