Tìm theo
Chlormezanone
Các tên gọi khác (9 ) :
  • (+-)-Chlormezanone
  • (±)-chlormezanone
  • 2-(P-Chlorophenyl)tetrahydro-3-methyl-4H-1,3-thiazin-4-one 1,1-dioxide
  • 2-(P-Chlorphenyl)-3-methyl-1,3-perhydrothiazin-4-on-1,1-dioxide
  • Chlormethazanone
  • Chlormezanona
  • Chlormezanone
  • Chlormezanonum
  • Clormezanona
Thuốc chống lo âu, hoảng sợ
Thuốc Gốc
Small Molecule
CAS: 80-77-3
ATC: M03BB02
CTHH: C11H12ClNO3S
PTK: 273.736
A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C11H12ClNO3S
Phân tử khối
273.736
Monoisotopic mass
273.022641652
InChI
InChI=1S/C11H12ClNO3S/c1-13-10(14)6-7-17(15,16)11(13)8-2-4-9(12)5-3-8/h2-5,11H,6-7H2,1H3
InChI Key
InChIKey=WEQAYVWKMWHEJO-UHFFFAOYSA-N
IUPAC Name
2-(4-chlorophenyl)-3-methyl-1$l^{6},3-thiazinane-1,1,4-trione
Traditional IUPAC Name
chlormezanone
SMILES
CN1C(C2=CC=C(Cl)C=C2)S(=O)(=O)CCC1=O
Độ tan chảy
116.2-118.6
Độ hòa tan
2500 mg/L (at 25 °C)
logP
1.3
logS
-2.2
pKa (strongest acidic)
19.07
pKa (Strongest Basic)
-2.5
PSA
54.45 Å2
Refractivity
64.88 m3·mol-1
Polarizability
25.89 Å3
Rotatable Bond Count
1
H Bond Acceptor Count
3
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Chlormezanone is a non-benzodiazepine muscle relaxant. It was discontinued worldwide in 1996 by its manufacturer due to confirmed serious and rare cutaneous reactions (toxic epidermal necrolysis).
Cơ Chế Tác Dụng : A non-benzodiazepine that is used in the management of anxiety. It has been suggested for use in the treatment of muscle spasm. [PubChem] Chlormezanone binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Độc Tính : Symptoms of overdose include drowsiness, weakness, nausea, dizziness, abdominal pain, cerebral oedema and renal tubular necrosis, hyperglycaemia and hypoglycaemia, liver damage, encephalopathy, coma and death.
Chỉ Định : Used in the management of anxiety and in the treatment of muscle spasm.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Fenaprim
  • Công ty : WinthropSreon
    Sản phẩm biệt dược : Trancopal
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01178
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2717
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505352
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00268
ChemSpider
http://www.chemspider.com/Chemical-Structure.2616.html
PharmGKB
http://www.pharmgkb.org/drug/PA448939
Wikipedia
http://en.wikipedia.org/wiki/Chlormezanone
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