Tìm theo
Chlormerodrin
Các tên gọi khác (5 ) :
  • {3-[(aminocarbonyl)amino]-2-methoxypropyl}chloromercury
  • 1-[3-(Chloromercuri)-2-methoxypropyl]urea
  • Chlormerodrina
  • Chlormerodrine
  • Chlormerodrinum
diagnostic agents, diuretics mercurial
Thuốc Gốc
Small Molecule
CAS: 62-37-3
CTHH: C5H11ClHgN2O2
PTK: 367.2
Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H11ClHgN2O2
Phân tử khối
367.2
Monoisotopic mass
368.021530917
InChI
InChI=1S/C5H11N2O2.ClH.Hg/c1-4(9-2)3-7-5(6)8;;/h4H,1,3H2,2H3,(H3,6,7,8);1H;/q;;+1/p-1
InChI Key
InChIKey=BJFGVYCULWBXKF-UHFFFAOYSA-M
IUPAC Name
[3-(chloromercurio)-2-methoxypropyl]urea
Traditional IUPAC Name
3-(chloromercurio)-2-methoxypropylurea
SMILES
COC(CNC(N)=O)C[Hg]Cl
Độ tan chảy
152.5 °C
Độ hòa tan
1.1E+004 mg/L (at 25 °C)
logP
-0.80
logS
-1.1
pKa (strongest acidic)
14.05
pKa (Strongest Basic)
-1.8
PSA
64.35 Å2
Refractivity
38.78 m3·mol-1
Polarizability
18.42 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
0
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Chlormerodrin is a mercurial compound with toxic side effects. It is no longer used and has been replaced with new classes of diuretic drugs.
Cơ Chế Tác Dụng : Chlormerodrin is a mercurial compound with toxic side effects that was previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool. It is no longer used and has been replaced with new classes of diuretic drugs. Chlormerodrin most likely acts by a direct renal action. Mercurial diuresis is presumed to occur through inhibition of reabsorption of water and electrolytes in the convoluted tubules, although the problem of whether the locus of action is primarily on the proximal or distal portion has not yet been settled. There is also evidence that mercurials interfere with the permeability of the membrane of tubular cells by increasing passive influx of Na+ ion, Cl- ion and water into the cells, without interfering with the active extrusion of Na+ ion. Lastly, there is some evidence that chlormerodrin inhibits succinic dehydrogenase, but the clinical significance of this binding is not known.
Độc Tính : As chlormerodrin has been shown to increase the levels of mercury in the kidney to toxic levels, any symptoms of overdose will most likely correspond to symptoms experienced in exposure to mercury.
Chỉ Định : Previously used as a diuretic. The radiolabeled form has been used as a diagnostic and research tool.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Parke Davis
    Sản phẩm biệt dược : Mercloran
  • Công ty : Parke Davis
    Sản phẩm biệt dược : Ormerdan
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00534
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=25210
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504793
ChemSpider
http://www.chemspider.com/Chemical-Structure.2615.html
PharmGKB
http://www.pharmgkb.org/drug/PA164748977
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