Tìm theo
Chlorcyclizine
Các tên gọi khác (4 ) :
  • Chlorcyclizin
  • Chlorcyclizine
  • Chlorcyclizinum
  • Clorciclizina
Thuốc chống dị ứng
Thuốc Gốc
Small Molecule
CAS: 82-93-9
CTHH: C18H21ClN2
PTK: 300.826
Chlorcyclizine is a first generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can be used as an antiemetic.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H21ClN2
Phân tử khối
300.826
Monoisotopic mass
300.139326389
InChI
InChI=1/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3
InChI Key
InChIKey=WFNAKBGANONZEQ-UHFFFAOYNA-N
IUPAC Name
1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine
Traditional IUPAC Name
chlorcyclizine
SMILES
CN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
Độ tan chảy
216
Độ hòa tan
4.24e-02 g/l
logP
4.15
logS
-3.9
pKa (Strongest Basic)
8
PSA
6.48 Å2
Refractivity
89.74 m3·mol-1
Polarizability
33.5 Å3
Rotatable Bond Count
3
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Động Học :
▧ Absorption :
Readily absorbed after oral administration and widely distributed throughout the body. Metabolised by N-demethylation to form norchlorcyclizine and by N-oxidation.
▧ Volume of Distribution :
After a single oral dose of 2 mg/kg to 4 subjects, average peak plasma concentrations of about 0.05 mg/L and 0.03 mg/L were attained in 5 h for unchanged drug and norchlorcyclizine, respectively. After oral administration of 50 mg 3 times a day for 6 days, plasma concentrations of norchlorcyclizine of 0.05 to 0.11 mg/L were reported on the first day after the cessation of treatment and plasma concentrations of 0.02 to 0.04 mg/L were found on the 10th day after cessation of treatment [Kuntzman et al. 1973].
▧ Protein binding :
about 85 to 90%.
▧ Metabolism :
High concentrations of the N-desmethyl metabolite are found in the liver, lungs, kidney, and spleen.
▧ Route of Elimination :
Slowly excreted in the urine; measurable amounts of norchlorcyclizine have been detected in the urine for up to 3 weeks after the cessation of chronic oral administration. About 0.5% of a single dose is excreted in the urine as the N-oxide.
▧ Half Life :
about 12 h.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Di-Paralene
  • Công ty :
    Sản phẩm biệt dược : Mantadil
  • Công ty :
    Sản phẩm biệt dược : Pruresidine
  • Công ty :
    Sản phẩm biệt dược : Trihistan
  • Công ty : New Chemical
    Sản phẩm biệt dược : Zimin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08936
Wikipedia
http://en.wikipedia.org/wiki/Chlorcyclizine
Drugs.com
http://www.drugs.com/international/chlorcyclizine.html
... loading
... loading