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Cetuximab
Các tên gọi khác (2) :
  • Anti EGFR
  • IMC-C225
Thuốc điều trị ung thư
Thuốc Gốc
Biotech
CAS: 205923-56-4
ATC: L01XC06
ĐG : Cardinal Health , http://www.cardinal.com
CTHH: C6484H10042N1732O2023S36
PTK: 145781.6000
Epidermal growth factor receptor binding FAB. Cetuximab is composed of the Fv (variable; antigen-binding) regions of the 225 murine EGFr monoclonal antibody specific for the N-terminal portion of human EGFr with human IgG1 heavy and kappa light chain constant (framework) regions.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6484H10042N1732O2023S36
Phân tử khối
145781.6000
Độ tan chảy
61 °C (FAB fragment), 71 °C (whole mAb)
Độ kỵ nước
-0.413
Điểm đẳng điện tích
8.48
Dược Lực Học : Used in the treatment of colorectal cancer, cetuximab binds specifically to the epidermal growth factor receptor (EGFr, HER1, c-ErbB-1) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Cetuximab competitively inhibits the binding of epidermal growth factor (EGF) and other ligands, such as transforming growth factor–alpha. Binding of cetuximab to the EGFr blocks phosphorylation and activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, decreased matrix metalloproteinase secretion and reduced vascular endothelial growth factor production.
Cơ Chế Tác Dụng : Epidermal growth factor receptor binding FAB. Cetuximab is composed of the Fv (variable; antigen-binding) regions of the 225 murine EGFr monoclonal antibody specific for the N-terminal portion of human EGFr with human IgG1 heavy and kappa light chain constant (framework) regions. Cetuximab binds to the epidermal growth factor receptor (EGFr) on both normal and tumor cells. EGFr is over-expressed in many colorectal cancers. Cetuximab competitively inhibits the binding of epidermal growth factor (EGF) and TGF alpha, thereby reducing their effects on cell growth and metastatic spread.
Dược Động Học :

▧ Half Life :
114 hrs
Độc Tính : Single doses of cetuximab higher than 500 mg/m2 have not been tested. There is no experience with overdosage in human clinical trials.
Chỉ Định : For treatment of EGFR-expressing metastatic colorectal cancer in patients who are refractory to other irinotecan-based chemotherapy regimens. Cetuximab is also indicated for treatment of squamous cell carcinoma of the head and neck in conjucntion with radiation therapy.
Liều Lượng & Cách Dùng : Solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00002
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/66733-948-23
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/J00228
PharmGKB
http://www.pharmgkb.org/drug/PA10040
Wikipedia
http://en.wikipedia.org/wiki/Cetuximab
RxList
http://www.rxlist.com/cgi/generic3/erbitux.htm
Drugs.com
http://www.drugs.com/cdi/cetuximab.html
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