Tìm theo
Cetrorelix
Các tên gọi khác (1) :
  • Cetrorelixum
Thuốc hormon và kháng hormon
Thuốc Gốc
Small Molecule
CAS: 120287-85-6
ATC: H01CC02
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C70H92ClN17O14
PTK: 1431.038
Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not ready for fertilization to be released. Cetrorelix does not allow the premature release of these eggs to occur.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C70H92ClN17O14
Phân tử khối
1431.038
Monoisotopic mass
1429.669818444
InChI
InChI=1S/C70H92ClN17O14/c1-39(2)31-52(61(94)82-51(15-9-28-77-69(73)74)68(101)88-30-10-16-58(88)67(100)79-40(3)59(72)92)83-60(93)50(14-8-29-78-70(75)102)81-63(96)54(34-43-20-25-49(91)26-21-43)86-66(99)57(38-89)87-65(98)56(36-45-11-7-27-76-37-45)85-64(97)55(33-42-18-23-48(71)24-19-42)84-62(95)53(80-41(4)90)35-44-17-22-46-12-5-6-13-47(46)32-44/h5-7,11-13,17-27,32,37,39-40,50-58,89,91H,8-10,14-16,28-31,33-36,38H2,1-4H3,(H2,72,92)(H,79,100)(H,80,90)(H,81,96)(H,82,94)(H,83,93)(H,84,95)(H,85,97)(H,86,99)(H,87,98)(H4,73,74,77)(H3,75,78,102)/t40-,50-,51+,52+,53-,54+,55-,56-,57+,58+/m1/s1
InChI Key
InChIKey=SBNPWPIBESPSIF-MHWMIDJBSA-N
IUPAC Name
(2S)-N-[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1R)-1-carbamoylethyl]carbamoyl}pyrrolidin-1-yl]-1-oxopentan-2-yl]-2-[(2R)-5-(carbamoylamino)-2-[(2S)-2-[(2S)-2-[(2R)-2-[(2R)-3-(4-chlorophenyl)-2-[(2R)-2-acetamido-3-(naphthalen-2-yl)propanamido]propanamido]-3-(pyridin-3-yl)propanamido]-3-hydroxypropanamido]-3-(4-hydroxyphenyl)propanamido]pentanamido]-4-methylpentanamide
Traditional IUPAC Name
cetrorelix
SMILES
CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CO)NC(=O)[C@@H](CC1=CN=CC=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O
Độ hòa tan
6.94e-03 g/l
logP
-1.7
logS
-5.3
pKa (strongest acidic)
9.49
pKa (Strongest Basic)
11.11
PSA
495.67 Å2
Refractivity
384.16 m3·mol-1
Polarizability
148.09 Å3
Rotatable Bond Count
38
H Bond Acceptor Count
18
H Bond Donor Count
17
Physiological Charge
1
Number of Rings
6
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Cetrorelix is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently luteinization as indicated by rising progesterone levels. Cetrorelix competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.
Cơ Chế Tác Dụng : Cetrorelix is a man-made hormone that blocks the effects of Gonadotropin Releasing Hormone (GnRH). GnRH controls another hormone that is called luteinizing hormone (LH), which is the hormone that starts ovulation during the menstrual cycle. When undergoing hormone treatment sometimes premature ovulation can occur, leading to eggs that are not ready for fertilization to be released. Cetrorelix does not allow the premature release of these eggs to occur. Cetrorelix binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion. It competes with natural GnRH for binding to membrane receptors on pituitary cells and thus controls the release of LH and FSH in a dose-dependent manner.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following subcutaneous injection. The mean absolute bioavailability following subcutaneous administration to healthy female subjects is 85%.
▧ Volume of Distribution :
* 1.16 L/kg
▧ Protein binding :
86%
▧ Metabolism :
In in vitro studies, cetrorelix was stable against phase I- and phase II-metabolism. Cetrorelix was transformed by peptidases, and the (1-4) peptide was the predominant metabolite.
▧ Route of Elimination :
Following subcutaneous administration of 10 mg cetrorelix to males and females, only unchanged cetrorelix was detected in urine.
▧ Half Life :
~62.8 hours
▧ Clearance :
* 1.28 ml/min·kg [adult healthy female with 3 mg single SC administration]
Chỉ Định : For the inhibition of premature LH surges in women undergoing controlled ovarian stimulation
Liều Lượng & Cách Dùng : Powder, for solution - Subcutaneous
Powder, for solution - Subcutaneous - 0.25 mg
Powder, for solution - Subcutaneous - 3 mg
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Cetrotide 0.25 mg kit
    Giá bán buôn : USD >137.99
    Đơn vị tính : kit
  • Biệt dược thương mại : Cetrotide 3 mg kit
    Giá bán buôn : USD >689.92
    Đơn vị tính : kit
Nhà Sản Xuất
  • Công ty : Merck
    Sản phẩm biệt dược : Cetrotide
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00050
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01685
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/44087-1225-1
PharmGKB
http://www.pharmgkb.org/drug/PA164764506
Wikipedia
http://en.wikipedia.org/wiki/Cetrorelix
RxList
http://www.rxlist.com/cgi/generic2/cetrorelix.htm
Drugs.com
http://www.drugs.com/cdi/cetrorelix-acetate.html
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