Tìm theo
Ceftizoxime
Các tên gọi khác (6 ) :
  • 7-[2-(2-Amino-thiazol-4-yl)-2-methoxyimino-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • CEFIZOX
  • Ceftizoxima
  • Ceftizoxime
  • Ceftizoximum
  • Syn-7-(2-(2-amino-4-thiazolyl)-2-methoxyiminoacetamido)-3-cephem-4-carboxylic acid
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 68401-81-0
ATC: J01DD07
ĐG : Baxter International Inc. , http://www.baxter.com
CTHH: C13H13N5O5S2
PTK: 383.403
A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H13N5O5S2
Phân tử khối
383.403
Monoisotopic mass
383.035809931
InChI
InChI=1S/C13H13N5O5S2/c1-23-17-7(5-4-25-13(14)15-5)9(19)16-8-10(20)18-6(12(21)22)2-3-24-11(8)18/h2,4,8,11H,3H2,1H3,(H2,14,15)(H,16,19)(H,21,22)/b17-7-/t8-,11-/m1/s1
InChI Key
InChIKey=NNULBSISHYWZJU-LLKWHZGFSA-N
IUPAC Name
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
ceftizoxime
SMILES
[H][C@]12SCC=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O
Độ tan chảy
277
Độ hòa tan
2.29e-01 g/l
logP
-0.85
logS
-3.2
pKa (strongest acidic)
3.13
pKa (Strongest Basic)
4.16
PSA
147.21 Å2
Refractivity
89.9 m3·mol-1
Polarizability
35.38 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
8
H Bond Donor Count
3
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Ceftizoxime is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders.
Cơ Chế Tác Dụng : A semisynthetic cephalosporin antibiotic which can be administered intravenously or by suppository. The drug is highly resistant to a broad spectrum of beta-lactamases and is active against a wide range of both aerobic and anaerobic gram-positive and gram-negative organisms. It has few side effects and is reported to be safe and effective in aged patients and in patients with hematologic disorders. [PubChem] Ceftizoxime is an aminothiazolyl cephalosporin with an extended spectrum of activity against many gram-negative, nosocomially acquired pathogens. It has excellent beta-lactamase stability, with good in vitro activity against Haemophilus influenzae, Neisseria gonorrhoeae and Klebsiella pneumoniae. Ceftizoxime, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that ceftizoxime interferes with an autolysin inhibitor.
Dược Động Học :

▧ Protein binding :
30% protein bound
▧ Metabolism :
Ceftizoxime is not metabolized, and is excreted virtually unchanged by the kidneys in 24 hours.
▧ Route of Elimination :
Ceftizoxime is not metabolized, and is excreted virtually unchanged by the kidneys in 24 hours.
Chỉ Định : For the treatment of infections due to susceptible strains of microorganisms.
Tương Tác Thuốc :
  • Amikacin Increased risk of nephrotoxicity
  • Gentamicin Increased risk of nephrotoxicity
  • Netilmicin Increased risk of nephrotoxicity
  • Probenecid Probenecid may increase the serum level of ceftizoxime.
  • Tobramycin Increased risk of nephrotoxicity
Liều Lượng & Cách Dùng : Solution - Intravenous
Tablet - Rectal
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01332
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6533629
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505647
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06890
ChemSpider
http://www.chemspider.com/Chemical-Structure.5018818.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0469-7271-01
PharmGKB
http://www.pharmgkb.org/drug/PA164748758
Wikipedia
http://en.wikipedia.org/wiki/Ceftizoxime
RxList
http://www.rxlist.com/cgi/generic/ceftizox.htm
Drugs.com
http://www.drugs.com/cdi/ceftizoxime.html
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