Tìm theo
Ceftibuten
Các tên gọi khác (5 ) :
  • (+)-(6R,7R)-7-((Z)-2-(2-amino-4-Thiazolyl)-4-carboxycrotonamido)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
  • Ceftibutene
  • Ceftibuteno
  • Ceftibutenum
  • cis-Ceftibuten
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 97519-39-6
ATC: J01DD14
ĐG : Schering Corp. , http://www.schering.de
CTHH: C15H14N4O6S2
PTK: 410.425
Ceftibuten is a third-generation cephalosporin antibiotic. It is an orally-administered agent. Cefalexin is used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H14N4O6S2
Phân tử khối
410.425
Monoisotopic mass
410.03547558
InChI
InChI=1S/C15H14N4O6S2/c16-15-17-7(5-27-15)6(1-2-9(20)21)11(22)18-10-12(23)19-8(14(24)25)3-4-26-13(10)19/h1,3,5,10,13H,2,4H2,(H2,16,17)(H,18,22)(H,20,21)(H,24,25)/b6-1-/t10-,13-/m1/s1
InChI Key
InChIKey=UNJFKXSSGBWRBZ-BJCIPQKHSA-N
IUPAC Name
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-4-carboxybut-2-enamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
ceftibuten
SMILES
[H][C@]12SCC=C(N1C(=O)[C@H]2NC(=O)C(=C/CC(O)=O)\C1=CSC(N)=N1)C(O)=O
Độ hòa tan
7.05e-02 g/l
logP
-1.4
logS
-3.8
pKa (strongest acidic)
2.99
pKa (Strongest Basic)
4.69
PSA
162.92 Å2
Refractivity
97.02 m3·mol-1
Polarizability
38.5 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
8
H Bond Donor Count
4
Physiological Charge
-2
Number of Rings
3
Bioavailability
1
Rule of Five
true
MDDR-Like Rule
true
Dược Lực Học : Ceftibuten is a third-generation cephalosporin antibiotic.
Cơ Chế Tác Dụng : Ceftibuten is a third-generation cephalosporin antibiotic. It is an orally-administered agent. Cefalexin is used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis. Ceftibuten exerts its bactericidal action by binding to essential target proteins of the bacterial cell wall. This binding leads to inhibition of cell-wall synthesis.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following oral administration.
▧ Volume of Distribution :
* 0.21 L/kg [adult subjects] * 0.5 L/kg [fasting pediatric patients]
▧ Protein binding :
Ceftibuten is 65% bound to plasma proteins. The protein binding is independent of plasma ceftibuten concentration.
▧ Metabolism :
A study with radiolabeled ceftibuten administered to 6 healthy adult male volunteers demonstrated that cis-ceftibuten is the predominant component in both plasma and urine. About 10% of ceftibuten is converted to the trans-isomer is approximately 1/8 as antimicrobially potent as the cis-isomer.
▧ Route of Elimination :
Ceftibuten is excreted in the urine; 95% of the administered radioactivity was recovered either in urine or feces.
Độc Tính : Overdosage of cephalosporins can cause cerebral irritation leading to convulsions.
Chỉ Định : Used to treat acute bacterial exacerbations of chronic bronchitis (ABECB), acute bacterial otitis media, pharyngitis, and tonsilitis.
Liều Lượng & Cách Dùng : Capsule - Oral
Suspension - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Cedax 400 mg capsule
    Giá bán buôn : USD >16.13
    Đơn vị tính : capsule
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Cedax
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01415
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=5282242
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507324
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08117
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00922
ChemSpider
http://www.chemspider.com/Chemical-Structure.4445418.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/45809-401-20
PharmGKB
http://www.pharmgkb.org/drug/PA164744555
Wikipedia
http://en.wikipedia.org/wiki/Ceftibuten
RxList
http://www.rxlist.com/cgi/generic/ceftibuten.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ced1075.shtml
Drugs.com
http://www.drugs.com/cdi/ceftibuten.html
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