Tìm theo
Cefradine
Các tên gọi khác (13 ) :
  • (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
  • (6R,7R)-7-{[(2R)-2-amino-2-cyclohexa-1,4-dien-1-ylacetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 7-(D-2-Amino-2-(1,4-cyclohexadienyl)acetamide)desacetoxycephalosporanicacid
  • Anspor
  • CED
  • Cefradina
  • Cefradine
  • Cefradinum
  • Cephradin
  • Cephradine
  • Eskacef
  • Sefril
  • Velosef
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 38821-53-3
ATC: J01DB09
ĐG : E.R. Squibb and Sons LLC
CTHH: C16H19N3O4S
PTK: 349.405
A semi-synthetic cephalosporin antibiotic. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H19N3O4S
Phân tử khối
349.405
Monoisotopic mass
349.109626801
InChI
InChI=1S/C16H19N3O4S/c1-8-7-24-15-11(14(21)19(15)12(8)16(22)23)18-13(20)10(17)9-5-3-2-4-6-9/h2-3,6,10-11,15H,4-5,7,17H2,1H3,(H,18,20)(H,22,23)/t10-,11-,15-/m1/s1
InChI Key
InChIKey=RDLPVSKMFDYCOR-UEKVPHQBSA-N
IUPAC Name
(6R,7R)-7-[(2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefradine
SMILES
[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CCC=CC1)C(O)=O
Độ tan chảy
140 °C
Độ hòa tan
2.13E+004 mg/L
logP
-2.4
logS
-2.6
pKa (strongest acidic)
3.46
pKa (Strongest Basic)
7.6
PSA
112.73 Å2
Refractivity
92 m3·mol-1
Polarizability
33.19 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Cơ Chế Tác Dụng : A semi-synthetic cephalosporin antibiotic. [PubChem] Cefradine is a first generation cephalosporin antibiotic with a spectrum of activity similar to Cefalexin. Cefradine, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that Cefradine interferes with an autolysin inhibitor.
Dược Động Học :

▧ Route of Elimination :
Over 90 percent of the drug is excreted unchanged in the urine within six hours.
Tương Tác Thuốc :
  • Amikacin Increased risk of nephrotoxicity
  • Gentamicin Increased risk of nephrotoxicity
  • Netilmicin Increased risk of nephrotoxicity
  • Probenecid Probenecid may increase the serum level of cefradine.
  • Tobramycin Increased risk of nephrotoxicity
Dữ Kiện Thương Mại
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01333
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=38103
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505082
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06897
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00264
ChemSpider
http://www.chemspider.com/Chemical-Structure.34933.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0003-0113-24
PharmGKB
http://www.pharmgkb.org/drug/PA448890
Wikipedia
http://en.wikipedia.org/wiki/Cefradine
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