Tìm theo
Cefprozil
Các tên gọi khác (5 ) :
  • Cefprozil
  • Cefprozil anhydrous
  • Cefprozilo
  • Cefprozilum
  • Cefzil
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 92665-29-7
ATC: J01DC10
ĐG : Apotex Inc. , http://www.apotex.com
CTHH: C18H19N3O5S
PTK: 389.426
Cefprozil is a cephalosporin antibiotic. It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H19N3O5S
Phân tử khối
389.426
Monoisotopic mass
389.104541423
InChI
InChI=1S/C18H19N3O5S/c1-2-3-10-8-27-17-13(16(24)21(17)14(10)18(25)26)20-15(23)12(19)9-4-6-11(22)7-5-9/h2-7,12-13,17,22H,8,19H2,1H3,(H,20,23)(H,25,26)/b3-2+/t12-,13-,17-/m1/s1
InChI Key
InChIKey=WDLWHQDACQUCJR-ZAMMOSSLSA-N
IUPAC Name
(6R,7R)-7-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-8-oxo-3-(prop-1-en-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefprozilo
SMILES
[H][C@]12SCC(C=CC)=C(N1C(=O)[C@@]2([H])NC(=O)[C@H](N)C1=CC=C(O)C=C1)C(O)=O
Độ tan chảy
218-225 °C
Độ hòa tan
55 mg/L
logP
0.6
logS
-3.4
pKa (strongest acidic)
3.53
pKa (Strongest Basic)
7.43
PSA
132.96 Å2
Refractivity
101.27 m3·mol-1
Polarizability
39.35 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
6
H Bond Donor Count
4
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Cefprozil, a semisynthetic, second-generation cephalosporin, is used to treat otitis media, soft-tissue infections, and respiratory tract infections.
Cơ Chế Tác Dụng : Cefprozil is a cephalosporin antibiotic. It can be used to treat bronchitis, ear infections, skin infections, and other bacterial infections. Cefprozil, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefprozil interferes with an autolysin inhibitor.
Dược Động Học :
▧ Absorption :
Oral bioavailability is approximately 95%.
▧ Volume of Distribution :
* 0.23 L/kg
▧ Protein binding :
36%
▧ Metabolism :
Cefprozil is eliminated primarily by the kidneys
▧ Half Life :
1.3 hours
▧ Clearance :
* 3 mL/min/kg [fasting subjects]
Độc Tính : Single 5000 mg/kg oral doses of cefprozil caused no mortality or signs of toxicity in adult, weaning or neonatal rats, or adult mice. A single oral dose of 3000 mg/kg caused diarrhea and loss of appetite in cynomolgus monkeys, but no mortality.
Chỉ Định : For the treatment of the following infections (respiratory, skin, soft tissue, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staph
Tương Tác Thuốc :
  • Probenecid Probenecid may increase the serum level of cefprozil.
Liều Lượng & Cách Dùng : Powder, for solution - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Brisoral
  • Công ty :
    Sản phẩm biệt dược : Cronocef
  • Công ty :
    Sản phẩm biệt dược : Serozil
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01150
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06888
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0087-7720-60
PharmGKB
http://www.pharmgkb.org/drug/PA164746342
Wikipedia
http://en.wikipedia.org/wiki/Cefprozil
RxList
http://www.rxlist.com/cgi/generic/cefprozi.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cef1077.shtml
Drugs.com
http://www.drugs.com/cdi/cefprozil.html
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