Tìm theo
Cefpodoxime
Các tên gọi khác (2) :
  • Cefpodoxima
  • Cefpodoximum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 82619-04-3
ATC: J01DD13
ĐG : Aurobindo Pharma Ltd. , http://www.aurobindo.com
CTHH: C15H17N5O6S2
PTK: 427.455
Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H17N5O6S2
Phân tử khối
427.455
Monoisotopic mass
427.062024681
InChI
InChI=1S/C15H17N5O6S2/c1-25-3-6-4-27-13-9(12(22)20(13)10(6)14(23)24)18-11(21)8(19-26-2)7-5-28-15(16)17-7/h5,9,13H,3-4H2,1-2H3,(H2,16,17)(H,18,21)(H,23,24)/b19-8-/t9-,13-/m1/s1
InChI Key
InChIKey=WYUSVOMTXWRGEK-HBWVYFAYSA-N
IUPAC Name
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefpodoxime
SMILES
[H][C@]12SCC(COC)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O
Độ hòa tan
1.85e-01 g/l
logP
-1.2
logS
-3.4
pKa (strongest acidic)
3.22
pKa (Strongest Basic)
4.16
PSA
156.44 Å2
Refractivity
100.71 m3·mol-1
Polarizability
39.9 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
9
H Bond Donor Count
3
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
MDDR-Like Rule
true
Dược Lực Học : Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. Notable exceptions include Pseudomonas aeruginosa, Enterococcus, and Bacteroides fragilis.
Cơ Chế Tác Dụng : Cefpodoxime is an oral third generation cephalosporin antibiotic. It is active against most Gram positive and Gram negative bacteria. It is commonly used to treat acute otitis media, pharyngitis, and sinusitis. Cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime. Cefpodoxime is active against a wide spectrum of Gram-positive and Gram-negative bacteria. Cefpodoxime is stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and cephalosporins, due to their production of beta-lactamase, may be susceptible to cefpodoxime. Cefpodoxime is inactivated by certain extended spectrum beta-lactamases. The bactericidal activity of cefpodoxime results from its inhibition of cell wall synthesis. The active metabolite of cefpodoxime binds preferentially to penicillin binding protein 3, which inhibits production of peptidoglycan, the primary constituent of bacterial cell walls.
Dược Động Học :
▧ Absorption :
Cefpodoxime proxetil is a prodrug that is absorbed from the gastrointestinal tract and de-esterified to its active metabolite, cefpodoxime. Following oral administration of 100 mg of cefpodoxime proxetil to fasting subjects, approximately 50% of the administered cefpodoxime dose was absorbed systemically.
▧ Protein binding :
22 to 33% in serum and from 21 to 29% in plasma.
▧ Route of Elimination :
Over the recommended dosing range (100 to 400 mg), approximately 29 to 33% of the administered cefpodoxime dose was excreted unchanged in the urine in 12 hours.
▧ Half Life :
2.09 to 2.84 hours
Chỉ Định : For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms.
Liều Lượng & Cách Dùng : Granule, for suspension - Oral
Tablet, film coated - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Banan
  • Công ty :
    Sản phẩm biệt dược : Doxef
  • Công ty :
    Sản phẩm biệt dược : Vantin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01416
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6335986
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504897
ChemSpider
http://www.chemspider.com/Chemical-Structure.4891496.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0009-3617-01
PharmGKB
http://www.pharmgkb.org/drug/PA164746385
Wikipedia
http://en.wikipedia.org/wiki/Cefpodoxime
RxList
http://www.rxlist.com/cgi/generic/vantin.htm
Drugs.com
http://www.drugs.com/cdi/cefpodoxime.html
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