Tìm theo
Cefpiramide
Các tên gọi khác (3) :
  • Cefpiramide
  • Cefpiramido
  • Cefpiramidum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 70797-11-4
ATC: J01DD11
CTHH: C25H24N8O7S2
PTK: 612.637
Cefpiramide is a third-generation cephalosporin antibiotic.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C25H24N8O7S2
Phân tử khối
612.637
Monoisotopic mass
612.120936542
InChI
InChI=1S/C25H24N8O7S2/c1-11-7-16(35)15(8-26-11)20(36)27-17(12-3-5-14(34)6-4-12)21(37)28-18-22(38)33-19(24(39)40)13(9-41-23(18)33)10-42-25-29-30-31-32(25)2/h3-8,17-18,23,34H,9-10H2,1-2H3,(H,26,35)(H,27,36)(H,28,37)(H,39,40)/t17-,18-,23-/m1/s1
InChI Key
InChIKey=PWAUCHMQEXVFJR-PMAPCBKXSA-N
IUPAC Name
(6R,7R)-7-[(2R)-2-[(4-hydroxy-6-methylpyridin-3-yl)formamido]-2-(4-hydroxyphenyl)acetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefpiramide
SMILES
[H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@@]2([H])NC(=O)[C@H](NC(=O)C1=C(O)C=C(C)N=C1)C1=CC=C(O)C=C1)C(O)=O
Độ hòa tan
6.68e-02 g/l
logP
-0.9
logS
-4
pKa (strongest acidic)
3.47
pKa (Strongest Basic)
2.66
PSA
212.76 Å2
Refractivity
164.81 m3·mol-1
Polarizability
58.79 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
11
H Bond Donor Count
5
Physiological Charge
-1
Number of Rings
5
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Cefpiramide is a cephalosporin active against Pseudomonas aeruginosa. It has a broad spectrum of antibacterial activity. Cefpiramide works by inhibiting bacterial cell wall biosynthesis. The plasma half-lives of cefpiramide in rabbits, dogs, and rhesus monkeys were much longer than those of cefoperazone and cefazolin.
Cơ Chế Tác Dụng : Cefpiramide is a third-generation cephalosporin antibiotic. The bactericidal activity of cefpiramide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Dược Động Học :
▧ Absorption :
Rapidly absorbed following intramuscular injection.
▧ Half Life :
4.44 hours
Độc Tính : Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Chỉ Định : For treatment of severe infections caused by susceptible bacteria such as P. aeruginosa.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00430
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C13376
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01904
PharmGKB
http://www.pharmgkb.org/drug/PA164748136
Wikipedia
http://en.wikipedia.org/wiki/Cefpiramide
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