Tìm theo
Cefotiam
Các tên gọi khác (4 ) :
  • (6R,7R)-7-[2-(2-Amino-thiazol-4-yl)-acetylamino]-3-[1-(2-dimethylamino-ethyl)-1H-tetrazol-5-ylsulfanylmethyl]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • CEFOTIAM
  • Cefotiamum
  • CTM
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 61622-34-2
ATC: J01DC07
CTHH: C18H23N9O4S3
PTK: 525.628
One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H23N9O4S3
Phân tử khối
525.628
Monoisotopic mass
525.103512339
InChI
InChI=1S/C18H23N9O4S3/c1-25(2)3-4-26-18(22-23-24-26)34-7-9-6-32-15-12(14(29)27(15)13(9)16(30)31)21-11(28)5-10-8-33-17(19)20-10/h8,12,15H,3-7H2,1-2H3,(H2,19,20)(H,21,28)(H,30,31)/t12-,15-/m1/s1
InChI Key
InChIKey=QYQDKDWGWDOFFU-IUODEOHRSA-N
IUPAC Name
(6R,7R)-7-[2-(2-amino-1,3-thiazol-4-yl)acetamido]-3-[({1-[2-(dimethylamino)ethyl]-1H-1,2,3,4-tetrazol-5-yl}sulfanyl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefotiam
SMILES
[H][C@]12SCC(CSC3=NN=NN3CCN(C)C)=C(N1C(=O)[C@H]2NC(=O)CC1=CSC(N)=N1)C(O)=O
Độ hòa tan
Soluble
logP
-2.1
logS
-2.6
pKa (strongest acidic)
2.79
pKa (Strongest Basic)
8.36
PSA
172.46 Å2
Refractivity
142.34 m3·mol-1
Polarizability
49.87 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
10
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
4
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Cefotiam is a third generation beta-lactam cephalosporin antibiotic. It has broad spectrum activity against Gram positive and Gram negative bacteria. It does not have activity against Pseudomonas aeruginosa. Cefotiam works by inhibiting bacterial cell wall biosynthesis.
Cơ Chế Tác Dụng : One of the cephalosporins that has a broad spectrum of activity against both gram-positive and gram-negative microorganisms. [PubChem] The bactericidal activity of cefotiam results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Dược Động Học :
▧ Absorption :
Rapidly absorbed following intramuscular injection. Bioavailability is 60% following intramuscular injection.
▧ Protein binding :
40%
▧ Half Life :
Approximately 1 hour.
Độc Tính : Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Chỉ Định : For treatment of severe infections caused by susceptible bacteria.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Ceradon
  • Sản phẩm biệt dược : Pansporin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00229
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=43708
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506679
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01819
ChemSpider
http://www.chemspider.com/Chemical-Structure.39831.html
PharmGKB
http://www.pharmgkb.org/drug/PA164749298
Wikipedia
http://en.wikipedia.org/wiki/Cefotiam
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