Tìm theo
Ceforanide
Các tên gọi khác (6 ) :
  • (6R,7R)-7-[[2-[2-(Aminomethyl)phenyl]acetyl]amino]-3-[[1-(carboxymethyl)tetrazol-5-yl]sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • 7-[O-(Aminomethyl)phenylacetamido]-3-[[[1-(carboxymethyl)-1H-tetrazol-5-yl]thio]methyl]-3-cephem-4-carboxylic acid
  • 7beta-[2-(Aminomethyl)phenyl]acetamido-3-{[1-(carboxymethyl)-1H-tetrazol-5-yl]sulfanyl}methyl-3,4-didehydrocepham-4-carboxylic acid
  • Ceforanide
  • Ceforanido
  • Ceforanidum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 60925-61-3
ATC: J01DC11
CTHH: C20H21N7O6S2
PTK: 519.554
Ceforanide is a second-generation parenteral cephalosporin antibiotic. It has a longer elimination half-life than any currently available cephalosporin. Its activity is very similar to that of cefamandole, a second-generation cephalosporin, except that ceforanide is less active against most gram-positive organisms. Many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to ceforanide, as are most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C20H21N7O6S2
Phân tử khối
519.554
Monoisotopic mass
519.099472819
InChI
InChI=1S/C20H21N7O6S2/c21-6-11-4-2-1-3-10(11)5-13(28)22-15-17(31)27-16(19(32)33)12(8-34-18(15)27)9-35-20-23-24-25-26(20)7-14(29)30/h1-4,15,18H,5-9,21H2,(H,22,28)(H,29,30)(H,32,33)/t15-,18-/m1/s1
InChI Key
InChIKey=SLAYUXIURFNXPG-CRAIPNDOSA-N
IUPAC Name
(6R,7R)-7-{2-[2-(aminomethyl)phenyl]acetamido}-3-({[1-(carboxymethyl)-1H-1,2,3,4-tetrazol-5-yl]sulfanyl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
ceforanide
SMILES
[H][C@]12SCC(CSC3=NN=NN3CC(O)=O)=C(N1C(=O)[C@H]2NC(=O)CC1=CC=CC=C1CN)C(O)=O
Độ hòa tan
1.97e-01 g/l
logP
-3.7
logS
-3.4
pKa (strongest acidic)
2.55
pKa (Strongest Basic)
9.14
PSA
193.63 Å2
Refractivity
139.87 m3·mol-1
Polarizability
49.27 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
10
H Bond Donor Count
4
Physiological Charge
-1
Number of Rings
4
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Ceforanide is a semisynthetic second-generation cephalosporin. The cephalosporins are bactericidal drugs with both gram-positive and gram-negative activity. They inhibit bacterial cell wall synthesis in a way similar to the penicillins.
Cơ Chế Tác Dụng : Ceforanide is a second-generation parenteral cephalosporin antibiotic. It has a longer elimination half-life than any currently available cephalosporin. Its activity is very similar to that of cefamandole, a second-generation cephalosporin, except that ceforanide is less active against most gram-positive organisms. Many coliforms, including Escherichia coli, Klebsiella, Enterobacter, and Proteus, are susceptible to ceforanide, as are most strains of Salmonella, Shigella, Hemophilus, Citrobacter and Arizona species. The bactericidal activity of ceforanide results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Dược Động Học :
▧ Absorption :
Rapidly absorbed following intramuscular injection.
▧ Protein binding :
80.6%
▧ Metabolism :
The major drug elimination route was urinary excretion with 85% of the dose being excreted unchanged in the urine within 12 hr, and no metabolites with antibiotic activity were observed in urine.
▧ Half Life :
2.6 to 2.98 hours
Độc Tính : Adverse effects following overdosage include nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Chỉ Định : For the treatment of infections caused by susceptible organisms.
Tương Tác Thuốc :
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Precef
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00923
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=43507
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504532
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06884
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00259
ChemSpider
http://www.chemspider.com/Chemical-Structure.39656.html
PharmGKB
http://www.pharmgkb.org/drug/PA164746057
Wikipedia
http://en.wikipedia.org/wiki/Ceforanide
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