Tìm theo
Cefonicid
Các tên gọi khác (4 ) :
  • (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-8-oxo-3-({[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cefonicid
  • Cefonicido
  • Cefonicidum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 61270-58-4
ATC: J01DC06
CTHH: C18H18N6O8S3
PTK: 542.566
A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C18H18N6O8S3
Phân tử khối
542.566
Monoisotopic mass
542.034823652
InChI
InChI=1S/C18H18N6O8S3/c25-13(9-4-2-1-3-5-9)14(26)19-11-15(27)24-12(17(28)29)10(6-33-16(11)24)7-34-18-20-21-22-23(18)8-35(30,31)32/h1-5,11,13,16,25H,6-8H2,(H,19,26)(H,28,29)(H,30,31,32)/t11-,13-,16-/m1/s1
InChI Key
InChIKey=DYAIAHUQIPBDIP-AXAPSJFSSA-N
IUPAC Name
(6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-8-oxo-3-({[1-(sulfomethyl)-1H-1,2,3,4-tetrazol-5-yl]sulfanyl}methyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefonicid
SMILES
[H][C@]12SCC(CSC3=NN=NN3CS(O)(=O)=O)=C(N1C(=O)[C@H]2NC(=O)[C@H](O)C1=CC=CC=C1)C(O)=O
Độ hòa tan
8.95e-01 g/l
logP
-2.5
logS
-2.8
pKa (strongest acidic)
-1.4
pKa (Strongest Basic)
-2.1
PSA
204.91 Å2
Refractivity
136.58 m3·mol-1
Polarizability
47.96 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
11
H Bond Donor Count
4
Physiological Charge
-2
Number of Rings
4
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Cefonicid is a second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections.
Cơ Chế Tác Dụng : A second-generation cephalosporin administered intravenously or intramuscularly. Its bactericidal action results from inhibition of cell wall synthesis. It is used for urinary tract infections, lower respiratory tract infections, and soft tissue and bone infections. [PubChem] Cefonicid, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
Dược Động Học :

▧ Protein binding :
98% bound to plasma proteins.
▧ Metabolism :
Not metabolized.
▧ Half Life :
4.5 hours
Chỉ Định : For the treatment of bacterial infections caused by susceptible microorganisms.
Tương Tác Thuốc :
  • Amikacin Increased risk of nephrotoxicity
  • Gentamicin Increased risk of nephrotoxicity
  • Netilmicin Increased risk of nephrotoxicity
  • Probenecid Probenecid may increase the serum level of cefonicib.
  • Tobramycin Increased risk of nephrotoxicity
Liều Lượng & Cách Dùng : Solution - Intramuscular
Solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Monocid
  • Công ty :
    Sản phẩm biệt dược : Praticef
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01328
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06882
PharmGKB
http://www.pharmgkb.org/drug/PA164743021
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