Tìm theo
Cefmenoxime
Các tên gọi khác (4 ) :
  • (6R,7R)-7-((Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-3-((1-methyl-1H-5-tetraazolylthio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure
  • (6R,7R)-7-[[(2e)-2-(2-amino-1,3-Thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (iupac)
  • Cefmenoxima
  • Cefmenoximum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 65085-01-0
ATC: J01DD05
CTHH: C16H17N9O5S3
PTK: 511.558
Cefmenoxime is a third-generation cephalosporin antibiotic. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H17N9O5S3
Phân tử khối
511.558
Monoisotopic mass
511.051476769
InChI
InChI=1S/C16H17N9O5S3/c1-24-16(20-22-23-24)33-4-6-3-31-13-9(12(27)25(13)10(6)14(28)29)19-11(26)8(21-30-2)7-5-32-15(17)18-7/h5,9,13H,3-4H2,1-2H3,(H2,17,18)(H,19,26)(H,28,29)/b21-8-/t9-,13-/m1/s1
InChI Key
InChIKey=HJJDBAOLQAWBMH-YCRCPZNHSA-N
IUPAC Name
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefmenoxime
SMILES
[H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O
Độ hòa tan
4.46e-01 g/l
logP
-1.3
logS
-3.1
pKa (strongest acidic)
3.04
pKa (Strongest Basic)
4.14
PSA
190.81 Å2
Refractivity
133.51 m3·mol-1
Polarizability
47.04 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
11
H Bond Donor Count
3
Physiological Charge
-1
Number of Rings
4
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Cefmenoxime is a semisynthetic beta-lactam cephalosporin antibiotic with activity similar to that of cefotaxime. It has broad spectrum activity against Gram positive and Gram negative bacteria.
Cơ Chế Tác Dụng : Cefmenoxime is a third-generation cephalosporin antibiotic. [Wikipedia] The bactericidal activity of cefmenoxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefmenoxime is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases.
Dược Động Học :
▧ Absorption :
Bioavailability is approximately 100% following intramuscular injection.
▧ Protein binding :
50-70%
▧ Metabolism :
Not appreciably metabolized.
▧ Half Life :
1 hour
Độc Tính : Information on cefmenoxime overdosage in humans is not available. However, with other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Chỉ Định : Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria.
Liều Lượng & Cách Dùng : Powder, for solution - Intramuscular
Powder, for solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Takeda
    Sản phẩm biệt dược : Bestcall
  • Công ty :
    Sản phẩm biệt dược : Cefmax
  • Công ty : Takeda
    Sản phẩm biệt dược : Tacef
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00267
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01739
PharmGKB
http://www.pharmgkb.org/drug/PA164750569
Wikipedia
http://en.wikipedia.org/wiki/Cefmenoxime
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