Tìm theo
Cefixime
Các tên gọi khác (5 ) :
  • (-)-Cefixim
  • Cefixim
  • Cefixima
  • Céfixime
  • Cefiximum
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 79350-37-1
ATC: J01DD08
ĐG : A-S Medication Solutions LLC , http://orders.a-smeds.com
CTHH: C16H15N5O7S2
PTK: 453.45
Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H15N5O7S2
Phân tử khối
453.45
Monoisotopic mass
453.041289239
InChI
InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1
InChI Key
InChIKey=OKBVVJOGVLARMR-QSWIMTSFSA-N
IUPAC Name
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefixime
SMILES
[H][C@]12SCC(C=C)=C(N1C(=O)[C@H]2NC(=O)C(=N/OCC(O)=O)\C1=CSC(N)=N1)C(O)=O
Độ tan chảy
218-225 °C
Độ hòa tan
55.11 mg/L
logP
-0.4
logS
-3.6
pKa (strongest acidic)
3.45
pKa (Strongest Basic)
2.92
PSA
184.51 Å2
Refractivity
104.91 m3·mol-1
Polarizability
41.62 Å3
Rotatable Bond Count
8
H Bond Acceptor Count
10
H Bond Donor Count
4
Physiological Charge
-2
Number of Rings
3
Bioavailability
1
Rule of Five
true
MDDR-Like Rule
true
Dược Lực Học : Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall.
Cơ Chế Tác Dụng : Cefixime, an antibiotic, is a third-generation cephalosporin like ceftriaxone and cefotaxime. Cefixime is highly stable in the presence of beta-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins due to the presence of beta-lactamases, may be susceptible to cefixime. The antibacterial effect of cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall. Like all beta-lactam antibiotics, cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.
Dược Động Học :
▧ Absorption :
About 40%-50% absorbed orally whether administered with or without food, however, time to maximal absorption is increased approximately 0.8 hours when administered with food.
▧ Protein binding :
65% (concentration independent)
▧ Metabolism :
Hepatic. Approximately 50% of the absorbed dose is excreted unchanged in the urine in 24 hours.
▧ Half Life :
3-4 hours (may range up to 9 hours). In severe renal impairment (5 to 20 mL/min creatinine clearance), the half-life increased to an average of 11.5 hours.
Độc Tính : Symptoms of overdose include blood in the urine, diarrhea, nausea, upper abdominal pain, and vomiting.
Chỉ Định : For use in the treatment of the following infections when caused by susceptible strains of the designated microorganisms: (1) uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis, (2) otitis media caused by Haemophilus influenzae (beta-lactamase positive and negative strains), Moraxella catarrhalis (most of which are beta-lactamase positive), and S. pyogenes, (3) pharyngitis and tonsillitis caused by S. pyogenes, (4) acute bronchitis and acute exacerbations of chronic bronchitis caused by Streptococcus pneumoniae and Haemophilus influenzae (beta-lactamase positive and negative strains), and (5) uncomplicated gonorrhea (cervical/urethral) caused by Neisseria gonorrhoeae (penicillinase- and non-penicillinase-producing strains).
Tương Tác Thuốc :
  • Probenecid Probenecid may increase the serum level of cefixime.
Liều Lượng & Cách Dùng : Powder, for suspension - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Menarini
    Sản phẩm biệt dược : Cefixoral
  • Công ty : GlaxoSmithKline
    Sản phẩm biệt dược : Cefspan
  • Công ty : Merck
    Sản phẩm biệt dược : Cephoral
  • Công ty : Solas
    Sản phẩm biệt dược : Fixam
  • Công ty : Invision
    Sản phẩm biệt dược : Fixspor
  • Công ty : Hetero
    Sản phẩm biệt dược : Hifen
  • Công ty : Infectopharm
    Sản phẩm biệt dược : InfectoOpticef
  • Công ty : Sanofi-Aventis
    Sản phẩm biệt dược : Kuracef
  • Công ty : Adley
    Sản phẩm biệt dược : Letix
  • Công ty : Delta
    Sản phẩm biệt dược : Ofex
  • Công ty : Abbott
    Sản phẩm biệt dược : Omnatax-O
  • Công ty : Micro Labs
    Sản phẩm biệt dược : Oracef
  • Công ty : Sanofi Aventis
    Sản phẩm biệt dược : Oroken
  • Công ty : Sandoz
    Sản phẩm biệt dược : Sancefix
  • Công ty : Novartis
    Sản phẩm biệt dược : Secef
  • Công ty : Teva
    Sản phẩm biệt dược : Supran
  • Công ty : Sanofi Aventis
    Sản phẩm biệt dược : Suprax
  • Công ty : Lupin
    Sản phẩm biệt dược : Suprax 125
  • Công ty : Merck
    Sản phẩm biệt dược : Tricef
  • Công ty : Firma
    Sản phẩm biệt dược : Unixime
  • Công ty : Merck
    Sản phẩm biệt dược : Uro-Cephoral
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00671
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06881
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00258
PharmGKB
http://www.pharmgkb.org/drug/PA164768821
Wikipedia
http://en.wikipedia.org/wiki/Cefixime
RxList
http://www.rxlist.com/cgi/generic/cefixime.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/sup1416.shtml
Drugs.com
http://www.drugs.com/cdi/cefixime.html
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