Tìm theo
Cefdinir
Các tên gọi khác (5 ) :
  • (6R,7R,Z)-7-(2-(2-Aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • (6R,7R)-7-{2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino}-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • Cefdinir
  • Cefdinirum
  • CFDN
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 91832-40-5
ATC: J01DD15
ĐG : Abbott Laboratories Ltd. , http://www.abbott.com
CTHH: C14H13N5O5S2
PTK: 395.414
Cefdinir (marketed by Abbott Laboratories under the brand name Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA) in December of 1997.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H13N5O5S2
Phân tử khối
395.414
Monoisotopic mass
395.035809931
InChI
InChI=1S/C14H13N5O5S2/c1-2-5-3-25-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-26-14(15)16-6/h2,4,8,12,24H,1,3H2,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1
InChI Key
InChIKey=RTXOFQZKPXMALH-GHXIOONMSA-N
IUPAC Name
(6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(N-hydroxyimino)acetamido]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefdinir
SMILES
[H][C@]12SCC(C=C)=C(N1C(=O)[C@H]2NC(=O)C(=N/O)\C1=CSC(N)=N1)C(O)=O
Độ hòa tan
8.78e-02 g/l
logP
-0.2
logS
-3.6
pKa (strongest acidic)
1.74
pKa (Strongest Basic)
7.45
PSA
158.21 Å2
Refractivity
94.34 m3·mol-1
Polarizability
36.12 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
8
H Bond Donor Count
4
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Cefdinir is a third generation cephalosporin with a broad spectrum of activity against enteric gram-negative rods. Cefdinir is stable in the presence of some, but not all, b-lactamase enzymes. As a result, many organisms resistant to penicillins and some cephalosporins are susceptible to cefdinir. Cephalosporins work the same way as penicillins: they interfere with the peptidoglycan synthesis of the bacterial wall by inhibiting the final transpeptidation needed for the cross-links. This effect is bactericidal.
Cơ Chế Tác Dụng : Cefdinir (marketed by Abbott Laboratories under the brand name Omnicef) is a semi-synthetic, broad-spectrum antibiotic in the third generation of the cephalosporin class, proven effective for common bacterial infections of the ear, sinus, throat, and skin. It was approved by the U.S. Food and Drug Administration (FDA) in December of 1997. As with other cephalosporins, bactericidal activity of cefdinir results from inhibition of cell wall synthesis by acting on penicillin binding proteins (PBPs).
Dược Động Học :
▧ Absorption :
Maximal plasma cefdinir concentrations occur 2 to 4 hours postdose following capsule or suspension administration. Estimated bioavailability of cefdinir capsules is 21% following administration of a 300 mg capsule dose, and 16% following administration of a 600 mg capsule dose. Estimated absolute bioavailability of cefdinir suspension is 25%. Absorption is reduced by approximately 15% when administered with a high fat meal.
▧ Volume of Distribution :
* 0.35±0.29 L/kg [adult subjects] * 0.67±0.38 L/kg [pediatric subjects (age 6 months to 12 years)]
▧ Protein binding :
60%-70%, binding is independent of concentration.
▧ Metabolism :
Cefdinir is not appreciably metabolized. Activity is primarily due to parent drug.
▧ Route of Elimination :
Cefdinir is not appreciably metabolized. Cefdinir is eliminated principally via renal excretion with a mean plasma elimination half-life (t½) of 1.7 (±0.6) hours.
▧ Half Life :
1.7 ± 0.6 hours
▧ Clearance :
* renal cl=2 +/- 1 mL/min/kg [healthy]
Độc Tính : Information on cefdinir overdosage in humans is not available. In acute rodent toxicity studies, a single oral 5600-mg/kg dose produced no adverse effects. Toxic signs and symptoms following overdosage with other b-lactam antibiotics have included nausea, vomiting, epigastric distress, diarrhea, and convulsions.
Chỉ Định : For the treatment of the respiratory, skin, soft tissue, and ENT infections caused by H. influenzae (including b-lactamase producing strains), H. parainfluenzae (including b-lactamase producing strains), S. pneumoniae (penicillin-susceptible strains), S. pyogenes, S. aureus (including b-lactamase producing strains), and M. catarrhalis.
Liều Lượng & Cách Dùng : Capsule - Oral
Powder, for suspension - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Abbott
    Sản phẩm biệt dược : Cednir
  • Công ty : Ranbaxy
    Sản phẩm biệt dược : Cefdiel
  • Công ty : Astellas
    Sản phẩm biệt dược : Cefzon
  • Công ty : Ranbaxy
    Sản phẩm biệt dược : Duocef
  • Công ty : Incepta
    Sản phẩm biệt dược : Efdinir
  • Công ty : Invision
    Sản phẩm biệt dược : Idinir
  • Công ty : Glenmark
    Sản phẩm biệt dược : Kefnir
  • Công ty : Sel-J
    Sản phẩm biệt dược : Nirocef
  • Công ty : Zuventus
    Sản phẩm biệt dược : Oceph
  • Công ty : Sel-J
    Sản phẩm biệt dược : Omicef
  • Sản phẩm biệt dược : Omnicef
  • Công ty : Janssen
    Sản phẩm biệt dược : Omnicef R
  • Công ty : Renata
    Sản phẩm biệt dược : Palacef
  • Công ty : Renata
    Sản phẩm biệt dược : Palcef
  • Công ty : Lupin
    Sản phẩm biệt dược : Rtist
  • Công ty : Siam Bheasach
    Sản phẩm biệt dược : Samnir
  • Công ty : Central Pharm
    Sản phẩm biệt dược : Xi Fu Ni
  • Công ty : Zydus
    Sản phẩm biệt dược : Zefdinir
  • Công ty : FDC
    Sản phẩm biệt dược : Zinir
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00535
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6915944
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505573
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08110
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00917
ChemSpider
http://www.chemspider.com/Chemical-Structure.5291705.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/65862-218-60
PharmGKB
http://www.pharmgkb.org/drug/PA164768739
Wikipedia
http://en.wikipedia.org/wiki/Cefdinir
RxList
http://www.rxlist.com/cgi/generic2/cefdin.htm
PDRhealth
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/omn1519.shtml
Drugs.com
http://www.drugs.com/cdi/cefdinir.html
... loading
... loading