Tìm theo
Cefalotin
Các tên gọi khác (12 ) :
  • 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid
  • 7-(2-Thienylacetamido)cephalosporanic acid
  • 7-(2'-Thienylacetamido)cephalosporanic acid
  • 7-(Thiophene-2-acetamido)cephalosporin
  • Cefalothin
  • Cefalotin
  • Cefalotina
  • Cefalotine
  • Cefalotinum
  • Cephalothin
  • Cephalotin
  • CET
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 153-61-7
ATC: J01DB03
CTHH: C16H16N2O6S2
PTK: 396.438
A cephalosporin antibiotic. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H16N2O6S2
Phân tử khối
396.438
Monoisotopic mass
396.044977634
InChI
InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1
InChI Key
InChIKey=XIURVHNZVLADCM-IUODEOHRSA-N
IUPAC Name
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefalotin
SMILES
[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)CC1=CC=CS1)C(O)=O
Độ tan chảy
160-160.5 °C
Độ hòa tan
158 mg/L
logP
0.00
logS
-3.9
pKa (strongest acidic)
3.63
pKa (Strongest Basic)
-3.3
PSA
113.01 Å2
Refractivity
93.79 m3·mol-1
Polarizability
37.22 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
5
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Cefalotin (INN) or cephalothin (USAN) is a semisynthetic first generation cephalosporin having a broad spectrum of antibiotic activity that is administered parenterally.
Cơ Chế Tác Dụng : A cephalosporin antibiotic. [PubChem] The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall compenent from being properly synthesized.
Dược Động Học :

▧ Protein binding :
65-80%
▧ Metabolism :
Metabolized to a less active desacetyl metabolite, although 50-75% of the drug is eliminated unchanged in the urine.
▧ Half Life :
30 minutes
Độc Tính : Rat intravenous LD50 is 4000 mg/kg.
Chỉ Định : Used to prevent infection during surgery and to treat many kinds of infections of the blood, bone or joints, respiratory tract, skin, and urinary tract.
Tương Tác Thuốc :
  • Amikacin Increased risk of nephrotoxicity
Liều Lượng & Cách Dùng : Powder, for solution - Intravenous
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Coaxin
  • Công ty : Lilly
    Sản phẩm biệt dược : Keflin
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00456
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6024
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509079
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07761
ChemSpider
http://www.chemspider.com/Chemical-Structure.5802.html
PharmGKB
http://www.pharmgkb.org/drug/PA448886
Wikipedia
http://en.wikipedia.org/wiki/Cefalotin
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