Tìm theo
Cefadroxil
Các tên gọi khác (9 ) :
  • (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  • CDX
  • Cefadroxil
  • Cefadroxil anhydrous
  • Cefadroxil monohydrate
  • Cefadroxilo
  • Cefadroxilum
  • Cephadroxil
  • D-Cefadroxil
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 66592-87-8
ATC: J01DB05
ĐG : Aidarex Pharmacuticals LLC , http://www.aidarex.com
CTHH: C16H17N3O5S
PTK: 363.388
Long-acting, broad-spectrum, water-soluble, cephalexin derivative. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H17N3O5S
Phân tử khối
363.388
Monoisotopic mass
363.088891359
InChI
InChI=1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1
InChI Key
InChIKey=BOEGTKLJZSQCCD-UEKVPHQBSA-N
IUPAC Name
(6R,7R)-7-[(2R)-2-amino-2-(4-hydroxyphenyl)acetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefadroxil
SMILES
[H][C@]12SCC(C)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=C(O)C=C1)C(O)=O
Độ tan chảy
197 °C
Độ hòa tan
1110 mg/L
logP
-0.4
logS
-3
pKa (strongest acidic)
3.45
pKa (Strongest Basic)
7.43
PSA
132.96 Å2
Refractivity
90.95 m3·mol-1
Polarizability
35.86 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
6
H Bond Donor Count
4
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Cefadroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.
Cơ Chế Tác Dụng : Long-acting, broad-spectrum, water-soluble, cephalexin derivative. [PubChem] Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor.
Dược Động Học :
▧ Absorption :
Cefadroxil is well absorbed on oral administration; food does not interfere with its absorption.
▧ Protein binding :
Binding rates of cefadroxil were 28.1% by U.F. method
▧ Route of Elimination :
Over 90% of the drug is excreted unchanged in the urine within 24 hours. It crosses the placenta and appears in breast milk.
▧ Half Life :
1.5 hours
Độc Tính : Nausea, vomiting, diarrhoea, allergic rashes may occur
Chỉ Định : For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes
Tương Tác Thuốc :
  • Probenecid Probenecid may increase the serum level of cefadroxil.
Liều Lượng & Cách Dùng : Capsule - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Cefadroxil 1 gm tablet
    Giá bán buôn : USD >7.14
    Đơn vị tính : tablet
  • Biệt dược thương mại : Duricef 1 gm tablet
    Giá bán buôn : USD >7.35
    Đơn vị tính : tablet
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01140
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06878
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00257
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0781-2938-50
PharmGKB
http://www.pharmgkb.org/drug/PA448835
Wikipedia
http://en.wikipedia.org/wiki/Cefadroxil
RxList
http://www.rxlist.com/cgi/generic/cefadrox.htm
Drugs.com
http://www.drugs.com/cdi/cefadroxil.html
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