Tìm theo
Cefaclor
Các tên gọi khác (10 ) :
  • 3-Chloro-7-D-(2-phenylglycinamido)-3-cephem-4-carboxylic acid
  • CCL
  • Cefaclor
  • Cefaclor
  • Cefaclor
  • Cefaclor anhydrous
  • Cefacloro
  • Cefaclorum
  • Céfeaclor
  • Cephaclor
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 53994-73-3
ATC: J01DC04
ĐG : Advanced Pharmaceutical Services Inc.
CTHH: C15H14ClN3O4S
PTK: 367.807
Semisynthetic, broad-spectrum antibiotic derivative of cephalexin. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H14ClN3O4S
Phân tử khối
367.807
Monoisotopic mass
367.039354348
InChI
InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
InChI Key
InChIKey=QYIYFLOTGYLRGG-GPCCPHFNSA-N
IUPAC Name
(6R,7R)-7-[(2R)-2-amino-2-phenylacetamido]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefaclor
SMILES
[H][C@]12SCC(Cl)=C(N1C(=O)[C@H]2NC(=O)[C@H](N)C1=CC=CC=C1)C(O)=O
Độ tan chảy
327 °C
Độ hòa tan
1E+004 mg/L
logP
0.4
logS
-3.2
pKa (strongest acidic)
3.03
pKa (Strongest Basic)
7.44
PSA
112.73 Å2
Refractivity
89.56 m3·mol-1
Polarizability
35.11 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
5
H Bond Donor Count
3
Physiological Charge
0
Number of Rings
3
Bioavailability
1
Rule of Five
true
Dược Lực Học : Cefaclor is a second generation cephalosporin antibiotic with a spectrum resembling first-generation cephalosporins. In vitro tests demonstrate that the bactericidal action of the cephalosporins results from inhibition of cell-wall synthesis. Cefaclor has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections: Gram positive aerobes - Staphylococci (including coagulase-positive, coagulase-negative, and penicillinase-producing strains), Streptococcus pneumoniae, and Streptococcus pyogenes (group A ß-hemolytic streptococci). Gram-negative aerobes - Escherichia coli, Haemophilus influenzae (including ß-lactamase-producing ampicillin-resistant strains), Klebsiella sp, and Proteus mirabilis.
Cơ Chế Tác Dụng : Semisynthetic, broad-spectrum antibiotic derivative of cephalexin. [PubChem] Cefaclor, like the penicillins, is a beta-lactam antibiotic. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that cefaclor interferes with an autolysin inhibitor.
Dược Động Học :
▧ Absorption :
Well absorbed after oral administration, independent of food intake.
▧ Protein binding :
23.5%
▧ Metabolism :
No appreciable biotransformation in liver (approximately 60% to 85% of the drug is excreted unchanged in the urine within 8 hours).
▧ Route of Elimination :
Approximately 60% to 85% of the drug is excreted unchanged in the urine within 8 hours, the greater portion being excreted within the first 2 hours.
▧ Half Life :
0.6-0.9 hour
Độc Tính : Symptoms of overdose include diarrhea, nausea, stomach upset, and vomiting.
Chỉ Định : For the treatment of certain infections caused by bacteria such as pneumonia and ear, lung, skin, throat, and urinary tract infections.
Tương Tác Thuốc :
  • Probenecid Probenecid may increase the serum level of cefaclor.
Liều Lượng & Cách Dùng : Capsule - Oral
Powder - Oral
Powder, for solution - Oral
Powder, for suspension - Oral
Suspension - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Sản phẩm biệt dược : Alenfral
  • Công ty : Galenika
    Sản phẩm biệt dược : Alfacet
  • Công ty : Dexo
    Sản phẩm biệt dược : Alfatil
  • Công ty : Dexo
    Sản phẩm biệt dược : Alfatil LP
  • Công ty : Lilly
    Sản phẩm biệt dược : Ceclor
  • Công ty : Lilly
    Sản phẩm biệt dược : Ceclor CD
  • Công ty : Flynn
    Sản phẩm biệt dược : Distaclor
  • Công ty : Alphapharm
    Sản phẩm biệt dược : Keflor
  • Công ty : Shionogi Seiyaku
    Sản phẩm biệt dược : Kefral
  • Công ty : Valeas
    Sản phẩm biệt dược : Panacef
  • Công ty : Eberth
    Sản phẩm biệt dược : Panoral
  • Sản phẩm biệt dược : Raniclor
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00833
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06877
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00256
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/63304-658-30
PharmGKB
http://www.pharmgkb.org/drug/PA164749137
Wikipedia
http://en.wikipedia.org/wiki/Cefaclor
RxList
http://www.rxlist.com/cgi/generic/cefaclor.htm
Drugs.com
http://www.drugs.com/cdi/cefaclor.html
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