Tìm theo
Cefacetrile
Các tên gọi khác (4 ) :
  • Cefacetrilo
  • Cefacetrilum
  • Cephacetrile
  • Vetrimast [veterinary]
Thuốc trị ký sinh trùng, chống nhiễm khuẩn
Thuốc Gốc
Small Molecule
CAS: 10206-21-0
ATC: J01DB10
CTHH: C13H13N3O6S
PTK: 339.324
A derivative of 7-aminocephalosporanic acid.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C13H13N3O6S
Phân tử khối
339.324
Monoisotopic mass
339.052505853
InChI
InChI=1S/C13H13N3O6S/c1-6(17)22-4-7-5-23-12-9(15-8(18)2-3-14)11(19)16(12)10(7)13(20)21/h9,12H,2,4-5H2,1H3,(H,15,18)(H,20,21)/t9-,12-/m1/s1
InChI Key
InChIKey=RRYMAQUWDLIUPV-BXKDBHETSA-N
IUPAC Name
(6R,7R)-3-[(acetyloxy)methyl]-7-(2-cyanoacetamido)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Traditional IUPAC Name
cefacetrile
SMILES
[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)CC#N)C(O)=O
Độ tan chảy
168-170
Độ hòa tan
2.43e+00 g/l
logP
-0.45
logS
-2.1
pKa (strongest acidic)
3.31
pKa (Strongest Basic)
-6.2
PSA
136.8 Å2
Refractivity
77.51 m3·mol-1
Polarizability
31.32 Å3
Rotatable Bond Count
6
H Bond Acceptor Count
6
H Bond Donor Count
2
Physiological Charge
-2
Number of Rings
2
Bioavailability
1
Rule of Five
true
Dược Lực Học : Cefacetrile is effective against many Gram-positive bacterial strains and somewhat less effective against Gram-negative species. It works by inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Cơ Chế Tác Dụng : A derivative of 7-aminocephalosporanic acid. In vitro tests demonstrate that the bactericidal action of cephalosporins results from inhibition of cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins.
Dược Động Học :

▧ Volume of Distribution :
Vd of 0.2 to 0.5L/.kg
▧ Protein binding :
23 to 38%
▧ Half Life :
1.2 hours
Chỉ Định : Cefacetrile is a broad-spectrum first generation cephalosporin antibiotic effective in Gram-positive and Gram-negative bacterial infections.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Ciba
    Sản phẩm biệt dược : Celospor
  • Công ty : Takeda
    Sản phẩm biệt dược : Celtol
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01414
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=91562
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504767
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07629
ChemSpider
http://www.chemspider.com/Chemical-Structure.82675.html
PharmGKB
http://www.pharmgkb.org/drug/PA164776752
Wikipedia
http://en.wikipedia.org/wiki/Cefacetrile
... loading
... loading