Tìm theo
Cathine
Các tên gọi khác (10 ) :
  • (+)-norephedrin
  • (+)-Norpseudoephedrine
  • (1S,2R)-(+)-Norephedrine
  • D-Cathine
  • D-norephedrine
  • D-phenylpropanolamine
  • Katine
  • norpseudoephedrine
  • Pseudonorephedrine
  • β-hydroxyamphetamine
appetite depressants
Thuốc Gốc
Small Molecule
CAS: 492-39-7
ATC: A08AA07
CTHH: C9H13NO
PTK: 151.2056
Cathine (β-hydroxyamphetamine) is a monoamine alkaloid found in the shrub Catha edulis (khat). Cathine is a Schedule III drug under the Convention on Psychotropic Substances. In the United States, it is classified as a Schedule IV controlled substance. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C9H13NO
Phân tử khối
151.2056
Monoisotopic mass
151.099714043
InChI
InChI=1S/C9H13NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7,9,11H,10H2,1H3/t7-,9+/m0/s1
InChI Key
InChIKey=DLNKOYKMWOXYQA-IONNQARKSA-N
IUPAC Name
(1S,2S)-2-amino-1-phenylpropan-1-ol
Traditional IUPAC Name
cathine
SMILES
C[C@H](N)[C@@H](O)C1=CC=CC=C1
Độ tan chảy
77.5-78 °C
Độ hòa tan
2E+004 mg/L (at 25 °C)
logP
0.83
logS
-0.87
pKa (strongest acidic)
13.9
pKa (Strongest Basic)
9.37
PSA
46.25 Å2
Refractivity
44.91 m3·mol-1
Polarizability
16.87 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Closely related to ephedrine, cathinone and other amphetamines, it may contribute to the stimulant effect of Catha edulis, although another constituent, cathinone appears to show stronger activity.
Dược Động Học :
▧ Absorption :
The mucosa of the oral cavity is considered to be the first absorption segment, where the major proportion of the alkaloids is absorbed (mean +/- SD: 84 +/- 6% for cathine). [PMID: 12848785]
▧ Half Life :
5.2 +/- 3.4 hours
Chỉ Định : Used to decrease appetite.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01486
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=441457
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46509110
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08300
ChemSpider
http://www.chemspider.com/Chemical-Structure.390189.html
Wikipedia
http://en.wikipedia.org/wiki/Cathine
... loading
... loading