Tìm theo
Carphenazine
Các tên gọi khác (2) :
  • Carfenazine
  • Carphenazin
Thuốc chống rối loạn tâm thần
Thuốc Gốc
Small Molecule
CAS: 2622-30-2
CTHH: C23H29N3O2S
PTK: 411.56
Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic psychoses.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H29N3O2S
Phân tử khối
411.56
Monoisotopic mass
411.198047877
InChI
InChI=1S/C23H29N3O2S/c1-2-21(28)18-7-8-23-20(17-18)26(19-5-3-4-6-22(19)29-23)14-13-24-9-11-25(12-10-24)15-16-27/h3-8,17,27H,2,9-16H2,1H3
InChI Key
InChIKey=DYCNETKPCXPXNW-UHFFFAOYSA-N
IUPAC Name
1-(10-{2-[4-(2-hydroxyethyl)piperazin-1-yl]ethyl}-10H-phenothiazin-2-yl)propan-1-one
Traditional IUPAC Name
carphenazine
SMILES
CCC(=O)C1=CC2=C(SC3=C(C=CC=C3)N2CCN2CCN(CCO)CC2)C=C1
Độ tan chảy
175-177
Độ hòa tan
9.05e-02 g/l
logP
3.3
logS
-3.7
pKa (strongest acidic)
15.56
pKa (Strongest Basic)
8
PSA
47.02 Å2
Refractivity
121.46 m3·mol-1
Polarizability
47.25 Å3
Rotatable Bond Count
7
H Bond Acceptor Count
5
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Carphenazine is a phenothiazine antipsychotic agent with a piperazine side-chain.
Cơ Chế Tác Dụng : Carphenazine is an antipsychotic drug, used in hospitalized patients in the management of chronic schizophrenic psychoses. A yellow, powdered, phenothiazine antipsychotic agent used in the treatment of acute or chronic schizophrenia. The term "phenothiazines" is used to describe the largest of the five main classes of neuroleptic antipsychotic drugs. These drugs have antipsychotic and, often, antiemetic properties, although they may also cause severe side effects such as akathisia, tardive dyskinesia and extrapyramidal symptoms. Carphenazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
Chỉ Định : Used in the treatment of acute or chronic schizophrenic reactions in hospitalized patients.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Procethazine
  • Công ty :
    Sản phẩm biệt dược : Proketazin
  • Công ty : Wyeth
    Sản phẩm biệt dược : Proketazine
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01038
PharmGKB
http://www.pharmgkb.org/drug/PA164750571
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