Tìm theo
Carbetocin
Các tên gọi khác (5 ) :
  • 1-Butanoic acid-2-(O-methyl-L-tyrosine)-1-carbaoxytocin
  • 1-Butyric acid-2-(3-(P-methoxyphenyl)-L-alanine)oxytocin
  • Carbetocino
  • Carbetocinum
  • Deamino-2-O-methyltyrosine-1-carbaoxytocin
oxytocics, delayed action preparations, anti tocolytic agents, labor induction agents
Thuốc Gốc
Small Molecule
CAS: 37025-55-1
ATC: H01BB03
CTHH: C45H69N11O12S
PTK: 988.161
Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C45H69N11O12S
Phân tử khối
988.161
Monoisotopic mass
987.484787417
InChI
InChI=1S/C45H69N11O12S/c1-6-25(4)38-44(66)51-28(15-16-34(46)57)40(62)52-31(21-35(47)58)41(63)54-32(23-69-18-8-10-37(60)50-30(42(64)55-38)20-26-11-13-27(68-5)14-12-26)45(67)56-17-7-9-33(56)43(65)53-29(19-24(2)3)39(61)49-22-36(48)59/h11-14,24-25,28-33,38H,6-10,15-23H2,1-5H3,(H2,46,57)(H2,47,58)(H2,48,59)(H,49,61)(H,50,60)(H,51,66)(H,52,62)(H,53,65)(H,54,63)(H,55,64)/t25-,28-,29-,30-,31-,32-,33-,38-/m0/s1
InChI Key
InChIKey=NSTRIRCPWQHTIA-DTRKZRJBSA-N
IUPAC Name
(2S)-2-{[(2S)-1-{[(3R,6S,9S,12S,15S)-12-[(2S)-butan-2-yl]-9-(2-carbamoylethyl)-6-(carbamoylmethyl)-15-[(4-methoxyphenyl)methyl]-5,8,11,14,17-pentaoxo-1-thia-4,7,10,13,16-pentaazacycloicosan-3-yl]carbonyl}pyrrolidin-2-yl]formamido}-N-(carbamoylmethyl)-4-methylpentanamide
Traditional IUPAC Name
carbetocin
SMILES
[H][C@]1(NC(=O)[C@H](CC2=CC=C(OC)C=C2)NC(=O)CCCSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)[C@@H](C)CC
Độ hòa tan
2.65e-02 g/l
logP
-2
logS
-4.6
pKa (strongest acidic)
11.42
PSA
362.51 Å2
Refractivity
250.18 m3·mol-1
Polarizability
101 Å3
Rotatable Bond Count
18
H Bond Acceptor Count
12
H Bond Donor Count
10
Physiological Charge
0
Number of Rings
3
Bioavailability
0
MDDR-Like Rule
true
Dược Lực Học : Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is sold under the trade name Duratocin. It is an analogue of oxytocin, and its action is similar to that of oxytocin; it causes contraction of the uterus.
Cơ Chế Tác Dụng : Carbetocin is a drug used to control postpartum hemorrhage, bleeding after giving birth. It is an analogue of oxytocin, and its action is similar to that of oxytocin -- it causes contraction of the uterus. Carbetocin binds to oxytocin receptors present on the smooth musculature of the uterus, resulting in rhythmic contractions of the uterus, increased frequency of existing contractions, and increased uterine tone. The oxytocin receptor content of the uterus is very low in the non-pregnant state, and increases during pregnancy, reaching a peak at the time of delivery.
Dược Động Học :
▧ Absorption :
Bioavailability is 80% following intramuscular injection.
▧ Half Life :
40 minutes
Chỉ Định : Used to control postpartum hemorrhage and bleeding after giving birth.
Tương Tác Thuốc :
  • Dinoprostone Dinoprostone may enhance the therapeutic effect of carbetocin. Avoid concomitant use of carbetocin with dinoprostone. The oxytocic activity of carbetocin (oxytocin analogue) may be augmented by agents used to promote cervical ripening (eg, dinoprostone, misoprostol). Dinoprostone (vaginal insert) prescribing information recommends waiting at least 30 minute following its removal before initiating treatment with oxytocic agents. A similar approach might be anticipated with misoprostol use.
  • Misoprostol Misoprostol may enhance the therapeutic effect of Carbetocin. Avoid the concomitant use of carbetocin and misoprostol. The oxytocic activity of carbetocin (oxytocin analogue) may be augmented by agents used to promote cervical ripening (eg, dinoprostone, misoprostol). Dinoprostone (vaginal insert) prescribing information recommends waiting at least 30 minute following its removal before initiating treatment with oxytocic agents. A similar approach might be anticipated with misoprostol use.
Liều Lượng & Cách Dùng : Liquid - Intravenous
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01282
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07229
PharmGKB
http://www.pharmgkb.org/drug/PA164743086
Wikipedia
http://en.wikipedia.org/wiki/Carbetocin
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