Tìm theo
Carbachol
Các tên gọi khác (14 ) :
  • (2-Carbamoyloxyethyl)trimethylammonium chloride
  • (2-Hydroxyethyl)trimethyl ammonium chloride carbamate
  • (2-Hydroxyethyl)trimethylammonium chloride carbamate
  • 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium chloride
  • 2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminum chloride
  • Carbachol chloride
  • Carbacholum
  • Carbacol
  • Carbamylcholine
  • Choline carbamate chloride
  • Choline chloride, carbamate
  • Choline chlorine carbamate
  • Karbachol
  • Karbamoylcholin chlorid
cardiotonic agents, analgesics non narcotic, cholinergic agonists, miotics
Thuốc Gốc
Small Molecule
CAS: 51-83-2
ATC: N07AB01, S01EB02
ĐG : Alcon Laboratories , http://www.alcon.com
CTHH: C6H15ClN2O2
PTK: 182.649
A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6H15ClN2O2
Phân tử khối
182.649
Monoisotopic mass
182.082205441
InChI
InChI=1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
InChI Key
InChIKey=AIXAANGOTKPUOY-UHFFFAOYSA-N
IUPAC Name
2-(trimethylazaniumyl)ethyl carbamate chloride
Traditional IUPAC Name
lentine chloride
SMILES
[Cl-].C[N+](C)(C)CCOC(N)=O
Độ tan chảy
208-210
Độ hòa tan
1 g/ml
logP
-3.78
logS
-2.3
pKa (strongest acidic)
15.23
PSA
52.32 Å2
Refractivity
50.02 m3·mol-1
Polarizability
16.02 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. In the cat and rat, carbachol is well-known for its ability to induce rapid eye movement (REM) sleep when microinjected into the pontine reticular formation. Carbachol elicits this REM sleep-like state via activation of postsynaptic muscarinic cholinergic receptors (mAChRs).
Cơ Chế Tác Dụng : A slowly hydrolyzed cholinergic agonist that acts at both muscarinic and nicotinic receptors. [PubChem] Carbachol is a parasympathomimetic that stimulates both muscarinic and nicotinic receptors. In topical ocular and intraocular administration its principal effects are miosis and increased aqueous humour outflow.
Dược Động Học :
▧ Absorption :
Not well absorbed in the gastro-intestinal tract, and does not cross the blood-brain barrier.
Độc Tính : Oral, mouse: LD50 = 15 mg/kg; Oral, rat: LD50 = 40 mg/kg.
Chỉ Định : Primarily used in the treatment of glaucoma, but is also used during ophthalmic surgery.
Tương Tác Thuốc :
  • Tacrine The acetylcholinesterase inhibitor, Tacrine, may increase the cholinergic effects of Carbachol, a cholinergic agonist. Monitor for increased cholinergic effects.
Liều Lượng & Cách Dùng : Liquid - Ophthalmic
Liquid - Subcutaneous
Solution - Intraocular
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00411
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00524
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/58768-735-12
PharmGKB
http://www.pharmgkb.org/drug/PA448784
Wikipedia
http://en.wikipedia.org/wiki/Carbachol
RxList
http://www.rxlist.com/cgi/generic2/carbachol.htm
Drugs.com
http://www.drugs.com/cdi/carbachol-drops.html
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