Tìm theo
Canfosfamide
Thuốc điều trị ung thư
Thuốc Gốc
Small Molecule
CAS: 439943-59-6
CTHH: C26H41Cl5N5O10PS
PTK: 823.935
Canfosfamide is an active agent in chemotherapy-resistant ovarian cancer.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C26H41Cl5N5O10PS
Phân tử khối
823.935
Monoisotopic mass
821.075438294
InChI
InChI=1S/C26H40Cl4N5O10PS.ClH/c27-7-11-34(12-8-28)46(42,35(13-9-29)14-10-30)45-15-16-47(43,44)18-22(33-23(36)6-5-21(31)26(40)41)24(37)32-17-19-3-1-2-4-20(19)25(38)39;/h1-4,21-22H,5-18,31H2,(H,32,37)(H,33,36)(H,38,39)(H,40,41);1H
InChI Key
InChIKey=KCMFHEVIGACFOM-UHFFFAOYSA-N
IUPAC Name
2-{[2-(4-amino-4-carboxybutanamido)-3-{[2-({bis[bis(2-chloroethyl)amino]phosphoryl}oxy)ethane]sulfonyl}propanamido]methyl}benzoic acid hydrochloride
Traditional IUPAC Name
2-{[2-(4-amino-4-carboxybutanamido)-3-[2-({bis[bis(2-chloroethyl)amino]phosphoryl}oxy)ethanesulfonyl]propanamido]methyl}benzoic acid hydrochloride
SMILES
Cl.NC(CCC(=O)NC(CS(=O)(=O)CCOP(=O)(N(CCCl)CCCl)N(CCCl)CCCl)C(=O)NCC1=CC=CC=C1C(O)=O)C(O)=O
logP
-2.9
pKa (strongest acidic)
1.4
pKa (Strongest Basic)
8.91
PSA
225.74 Å2
Refractivity
177.19 m3·mol-1
Polarizability
74.81 Å3
Rotatable Bond Count
25
H Bond Acceptor Count
11
H Bond Donor Count
5
Physiological Charge
-1
Number of Rings
1
Bioavailability
0
Cơ Chế Tác Dụng : Canfosfamide is an active agent in chemotherapy-resistant ovarian cancer. S-transferase P1-1 (GST P1-1) is an enzyme overexpressed in many human cancer cells. High levels of GST P1-1 are associated with a poor prognosis and resistance to certain chemotherapeutics. The activation of canfosfamide occurs when GST P1-1 splits canfosfamide into two active fragments: a glutathione analog fragment and an active cytotoxic fragment. The cytotoxic fragment reacts with important cell components, including RNA, DNA and proteins, leading to cell death. The glutathione analog fragment of canfosfamide may remain bound to GST P1-1, which may limit the ability of GST P1-1 to inactivate other cancer drugs.
Dược Động Học :

▧ Half Life :
18 min
Độc Tính : Canfosfamide-related toxicities included grade 1-2 nausea, vomiting, fatigue, transient microscopic hematuria, and anemia.
Chỉ Định : Intended for the treatment of various forms of cancer.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Telcyta
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04972
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6433120
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=10549844
ChemSpider
http://www.chemspider.com/Chemical-Structure.4938308.html
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