Tìm theo
Calusterone
Các tên gọi khác (11 ) :
  • 17-beta-Hydroxy-7-beta,17-alpha-dimethylandrost-4-ene-3-one
  • 17beta-Hydroxy-7beta,17-dimethylandrost-4-en-3-one
  • 17beta-Hydroxy-7beta,17alpha-dimethylandrost-4-ene-3-one
  • 7-beta,17-alpha-Dimethyl testosterone
  • 7-beta,17-Dimethyltestosterone
  • 7beta,17-Dimethyltestosterone
  • 7beta,17alpha-Dimethyltestosterone
  • Calusteron
  • Calusterona
  • Calusteronum
  • CLS
Thuốc Gốc
Small Molecule
CAS: 17021-26-0
CTHH: C21H32O2
PTK: 316.4776
A 17-alkylated orally active androgenic steroid. A Schedule IV drug in Canada.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C21H32O2
Phân tử khối
316.4776
Monoisotopic mass
316.240230268
InChI
InChI=1S/C21H32O2/c1-13-11-14-12-15(22)5-8-19(14,2)16-6-9-20(3)17(18(13)16)7-10-21(20,4)23/h12-13,16-18,23H,5-11H2,1-4H3/t13-,16-,17-,18+,19-,20-,21-/m0/s1
InChI Key
InChIKey=IVFYLRMMHVYGJH-PVPPCFLZSA-N
IUPAC Name
(1S,2R,9S,10R,11S,14S,15S)-14-hydroxy-2,9,14,15-tetramethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
Traditional IUPAC Name
calusterone
SMILES
[H][C@@]12CC[C@](C)(O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@@H](C)CC2=CC(=O)CC[C@]12C
Độ tan chảy
128 °C
Độ hòa tan
1.12e-02 g/l
logP
3.93
logS
-4.5
pKa (strongest acidic)
19.56
pKa (Strongest Basic)
-0.53
PSA
37.3 Å2
Refractivity
93.62 m3·mol-1
Polarizability
37.77 Å3
Rotatable Bond Count
0
H Bond Acceptor Count
2
H Bond Donor Count
1
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Calusterone is a 17-alkylated orally active androgenic steroid. Calusterone may alter the metabolism of estradiol and reduce estrogen production. Calusterone has been investigated for possible antitumor properties.
Cơ Chế Tác Dụng : A 17-alkylated orally active androgenic steroid. A Schedule IV drug in Canada. The effects of calusterone in humans most likely occur by way of two main mechanisms: by activation of the androgen receptor, and by conversion to estradiol and activation of certain estrogen receptors. Using testosterone as the prime example, free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. DHT binds to the same androgen receptor even more strongly than T, so that its androgenic potency is about 2.5 times that of T. The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
Chỉ Định : An anabolic steroid which can theoretically aid in restauration and buildup of certain tissues, especially muscle. It is similar to synthetic testosterone and is still in early investigation. It was also investigated for use as a treatment for metastatic breast cancer.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Methosarb
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01564
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=28204
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507441
ChemSpider
http://www.chemspider.com/Chemical-Structure.26239.html
... loading
... loading