Tìm theo
Calcium Gluceptate
Các tên gọi khác (13 ) :
  • Calcii Glucoheptonas
  • Calcii glugoheptonas
  • Calcium (2XI)-D-gluco-heptonate
  • Calcium bis[(2XI)-D-glycero-D-gulo-heptonate]
  • Calcium bis[(2XI)-D-glycero-D-ido-heptonate]
  • Calcium bis[(3R,4S,5R,6R)-2,3,4,5,6,7-hexahydroxyheptanoate]
  • Calcium Gluceptate
  • Calcium glucoheptonat
  • Calcium glucoheptonate
  • Calcium glucoheptonate (1:2)
  • Glucoheptonate de calcium
  • Glucoheptonato calcico
  • Trimethylene chlorobromide
antihypermagnesemic agents, antihypocalcemic agents, electrolyte replenisher, supplements
Thuốc Gốc
Small Molecule
CAS: 29039-00-7
ĐG : Draxis Specialty Pharmaceuticals Inc. , http://www.draxispharma.com
CTHH: C14H26CaO16
PTK: 490.425
Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones. Calcium is also needed for the heart, muscles, and nervous system to work properly.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C14H26CaO16
Phân tử khối
490.425
Monoisotopic mass
490.084675939
InChI
InChI=1S/2C7H14O8.Ca/c2*8-1-2(9)3(10)4(11)5(12)6(13)7(14)15;/h2*2-6,8-13H,1H2,(H,14,15);/q;;+2/p-2/t2*2-,3-,4+,5-,6?;/m11./s1
InChI Key
InChIKey=FATUQANACHZLRT-KMRXSBRUSA-L
IUPAC Name
calcium bis((3R,4S,5R,6R)-2,3,4,5,6,7-hexahydroxyheptanoate)
Traditional IUPAC Name
calcium bis((2xi)-D-gluco-heptonate)
SMILES
[Ca++].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)C([O-])=O
Độ hòa tan
Soluble
logP
-4
logS
-1.1
pKa (strongest acidic)
3.38
pKa (Strongest Basic)
-3
PSA
161.51 Å2
Refractivity
55.07 m3·mol-1
Polarizability
19.35 Å3
Rotatable Bond Count
12
H Bond Acceptor Count
8
H Bond Donor Count
6
Physiological Charge
-1
Number of Rings
0
Bioavailability
0
Dược Lực Học : Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones. Calcium is also needed for the heart, muscles, and nervous system to work properly. The bones serve as a storage site for the body's calcium. They are continuously giving up calcium to the bloodstream and then replacing it as the body's need for calcium changes from day to day. When there is not enough calcium in the blood to be used by the heart and other organs, your body will take the needed calcium from the bones. When you eat foods rich in calcium, the calcium will be restored to the bones and the balance between your blood and bones will be maintained.
Cơ Chế Tác Dụng : Calcium supplements such as calcium gluceptate are taken by individuals who are unable to get enough calcium in their regular diet or who have a need for more calcium. They are used to prevent or treat several conditions that may cause hypocalcemia (not enough calcium in the blood). The body needs calcium to make strong bones. Calcium is also needed for the heart, muscles, and nervous system to work properly. Calcium gluceptate replenishes the deminished levels of calcium in the body, returning them to normal levels.
Dược Động Học :
▧ Absorption :
Rapidly absorbed following oral administration.
Độc Tính : Symptoms of overdose include confusion, drowsiness (severe), high blood pressure, increased sensitivity of eyes or skin to light, irregular, fast, or slow heartbeat, and unusually large amount of urine or increased frequency of urination.
Chỉ Định : For treatment of mild hypocalcemia due to neonatal tetany, tetany due to parathyroid deficiency or vitamin D deficiency, and alkalosis, as prophylaxis of hypocalcemia during exchange transfusions, in the treatment of intestinal malabsorption, and to replenish electrolytes.
Tương Tác Thuốc :
  • Trovafloxacin Calcium may decrease the absorption of orally administered Trovafloxacin. Administer Trovafloxacin 2 hours before or 6 hours after a dose of the calcium containing agent to minimize the interaction.
Liều Lượng & Cách Dùng : Solution - Intravenous
Solution - Oral
Dữ Kiện Thương Mại
Giá thị trường
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00326
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=62859
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507233
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00934
ChemSpider
http://www.chemspider.com/Chemical-Structure.56591.html
PharmGKB
http://www.pharmgkb.org/drug/PA164746233
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