Tìm theo
Butenafine
Các tên gọi khác (7 ) :
  • (4-Tert-butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine
  • (4-Tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine
  • 4-Tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine
  • Butenafina
  • Butenafine
  • Butenafinum
  • N-(P-Tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine
antifungal agents
Thuốc Gốc
Small Molecule
CAS: 101828-21-1
ATC: D01AE23
ĐG : Erregierre SPA , http://www.erregierre.it
CTHH: C23H27N
PTK: 317.4672
Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H27N
Phân tử khối
317.4672
Monoisotopic mass
317.214349869
InChI
InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3
InChI Key
InChIKey=ABJKWBDEJIDSJZ-UHFFFAOYSA-N
IUPAC Name
[(4-tert-butylphenyl)methyl](methyl)(naphthalen-1-ylmethyl)amine
Traditional IUPAC Name
butenafine
SMILES
CN(CC1=CC=C(C=C1)C(C)(C)C)CC1=CC=CC2=CC=CC=C12
Độ hòa tan
Slightly soluble (HCl salt)
logP
6.6
logS
-6.6
pKa (Strongest Basic)
9.23
PSA
3.24 Å2
Refractivity
104.33 m3·mol-1
Polarizability
38.41 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Dược Lực Học : Butenafine is a synthetic antifungal agent that is structurally and pharmacologically related to allylamine antifungals. The exact mechanism of action has not been established, but it is suggested that butenafine's antifungal activity is exerted through the alteration of cellular membranes, which results in increased membrane permeability, and growth inhibition. Butenafine is mainly active against dermatophytes and has superior fungicidal activity against this group of fungi when compared to that of terbinafine, naftifine, tolnaftate, clotrimazole, and bifonazole. It is also active against Candida albicans and this activity is superior to that of terbinafine and naftifine. Butenafine also generates low MICs for Cryptococcus neoformans and Aspergillus spp. as well.
Cơ Chế Tác Dụng : Butenafine hydrochloride is a synthetic benzylamine antifungal agent. Butenafine works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes. Although the mechanism of action has not been fully established, it has been suggested that butenafine, like allylamines, interferes with sterol biosynthesis (especially ergosterol) by inhibiting squalene monooxygenase, an enzyme responsible for converting squalene to 2,3-oxydo squalene. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Blockage of squalene monooxygenase also leads to a subsequent accumulation of squalene. When a high concentration of squalene is reached, it is thought to have an effect of directly kill fungal cells.
Dược Động Học :
▧ Absorption :
The total amount absorbed through the skin into the systemic circulation has not been quantified.
▧ Metabolism :
The primary metabolite in urine was formed through hydroxylation at the terminal t-butyl side-chain.
▧ Half Life :
Following topical application, a biphasic decline of plasma butenafine concentrations was observed with the half-lives estimated to be 35 hours initial and over 150 hours terminal.
Chỉ Định : For the topical treatment of the following dermatologic infections: tinea (pityriasis) versicolor due to M. furfur, interdigital tinea pedis (athlete’s foot), tinea corporis (ringworm) and tinea cruris (jock itch) due to E. floccosum, T. mentagrophytes, T. rubrum, and T. tonsurans.
Liều Lượng & Cách Dùng : Cream - Topical
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Mentax
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01091
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2484
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506191
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C08067
ChemSpider
http://www.chemspider.com/Chemical-Structure.2390.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0378-6151-46
PharmGKB
http://www.pharmgkb.org/drug/PA164745478
Wikipedia
http://en.wikipedia.org/wiki/Butenafine
RxList
http://www.rxlist.com/cgi/generic2/butenafine.htm
Drugs.com
http://www.drugs.com/cdi/butenafine-cream.html
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