Tìm theo
Brompheniramine
Các tên gọi khác (10 ) :
  • [3-(4-Bromo-phenyl)-3-pyridin-2-yl-propyl]-dimethyl-amine
  • 1-(P-Bromophenyl)-1-(2-pyridyl)-3-dimethylaminopropane
  • 2-(P-Bromo-alpha-(2-dimethylaminoethyl)benzyl)pyridine
  • 3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine
  • 3-(P-Bromophenyl)-3-(2-pyridyl)-N,N-dimethylpropylamine
  • BPN
  • Bromfeniramina
  • Brompheniramin
  • Bromphéniramine
  • Brompheniraminum
Thuốc chống dị ứng
Thuốc Gốc
Small Molecule
CAS: 86-22-6
ATC: R06AB01
ĐG : Anip Acquisition Co.
CTHH: C16H19BrN2
PTK: 319.239
Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C16H19BrN2
Phân tử khối
319.239
Monoisotopic mass
318.073161265
InChI
InChI=1S/C16H19BrN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
InChI Key
InChIKey=ZDIGNSYAACHWNL-UHFFFAOYSA-N
IUPAC Name
[3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
Traditional IUPAC Name
brompheniramine
SMILES
CN(C)CCC(C1=CC=C(Br)C=C1)C1=CC=CC=N1
Độ tan chảy
< 25 °C
Độ sôi
149.5 °C at 5.00E-01 mm Hg
Độ hòa tan
Freely soluble (maleate salt)
logP
3.4
logS
-4.4
pKa (Strongest Basic)
9.48
PSA
16.13 Å2
Refractivity
83.67 m3·mol-1
Polarizability
32.08 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
2
H Bond Donor Count
0
Physiological Charge
1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Brompheniramine is an antihistaminergic medication of the propylamine class. It is a first-generation antihistamine. In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Brompheniramine is a histamine H1 antagonist (or more correctly, an inverse histamine agonist) of the alkylamine class. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Cơ Chế Tác Dụng : Histamine H1 antagonist used in treatment of allergies, rhinitis, and urticaria. [PubChem] Brompheniramine works by acting as an antagonist of the H1 histamine receptors. It also functions as a moderately effective anticholingeric agent, likely an antimuscarinic agent similar to other common antihistamines such as diphenhydramine. Its effects on the cholinergic system may include side-effects such as drowsiness, sedation, dry mouth, dry throat, blurred vision, and increased heart rate.
Dược Động Học :
▧ Absorption :
Antihistamines are well absorbed from the gastrointestinal tract after oral administration.
▧ Metabolism :
Hepatic (cytochrome P-450 system), some renal.
Độc Tính : Oral, rat: LD50 = 318 mg/kg. Signs of overdose include fast or irregular heartbeat, mental or mood changes, tightness in the chest, and unusual tiredness or weakness.
Chỉ Định : For the treatment of the symptoms of the common cold and allergic rhinitis, such as runny nose, itchy eyes, watery eyes, and sneezing.
Tương Tác Thuốc :
  • Donepezil Possible antagonism of action
  • Galantamine Possible antagonism of action
  • Rivastigmine Possible antagonism of action
  • Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Brompheniramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
  • Trimethobenzamide Trimethobenzamide and Brompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
  • Triprolidine Triprolidine and Brompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
  • Trospium Trospium and Brompheniramine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00835
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=6834
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508137
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06857
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00663
ChemSpider
http://www.chemspider.com/Chemical-Structure.6573.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50017666
PharmGKB
http://www.pharmgkb.org/drug/PA448675
Wikipedia
http://en.wikipedia.org/wiki/Brompheniramine
Drugs.com
http://www.drugs.com/cdi/brompheniramine-12-hour-sustained-release-tablets.html
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