Tìm theo
Bromfenac
Các tên gọi khác (4 ) :
  • [2-Amino-3-(4-bromo-benzoyl)-phenyl]-acetic acid
  • 2-amino-3-(4-Bromobenzoyl)benzeneacetic acid
  • Bromfenaco
  • Bromfenacum
Thuốc Gốc
Small Molecule
CAS: 91714-94-2
ĐG : Bausch & Lomb Inc. , http://www.bausch.com
CTHH: C15H12BrNO3
PTK: 334.165
Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool to optimize surgical outcomes.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C15H12BrNO3
Phân tử khối
334.165
Monoisotopic mass
333.000055902
InChI
InChI=1S/C15H12BrNO3/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19/h1-7H,8,17H2,(H,18,19)
InChI Key
InChIKey=ZBPLOVFIXSTCRZ-UHFFFAOYSA-N
IUPAC Name
2-{2-amino-3-[(4-bromophenyl)carbonyl]phenyl}acetic acid
Traditional IUPAC Name
bromfenac
SMILES
NC1=C(CC(O)=O)C=CC=C1C(=O)C1=CC=C(Br)C=C1
Độ hòa tan
1.26e-02 g/l
logP
3.4
logS
-4.4
pKa (strongest acidic)
3.81
pKa (Strongest Basic)
1.59
PSA
80.39 Å2
Refractivity
80.26 m3·mol-1
Polarizability
29.93 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Bromfenac ophthalmic solution is a sterile, topical, nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use.
Cơ Chế Tác Dụng : Bromfenac is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool to optimize surgical outcomes. The mechanism of its action is thought to be due to its ability to block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. In studies performed in animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilation, increased vascular permeability, leukocytosis, and increased intraocular pressure.
Dược Động Học :
▧ Absorption :
The plasma concentration of bromfenac following ocular administration in humans is unknown.
Chỉ Định : For the treatment of postoperative inflammation in patients who have undergone cataract extraction.
Tương Tác Thuốc :
Liều Lượng & Cách Dùng : Solution / drops - Ophthalmic
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00963
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=60726
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508121
ChemSpider
http://www.chemspider.com/Chemical-Structure.54730.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/67425-004-50
PharmGKB
http://www.pharmgkb.org/drug/PA448670
Wikipedia
http://en.wikipedia.org/wiki/Bromfenac
RxList
http://www.rxlist.com/cgi/generic4/xibrom.htm
Drugs.com
http://www.drugs.com/cdi/bromfenac.html
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