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Botulinum Toxin Type B
Các tên gọi khác (2) :
  • Botulinum neurotoxin type B precursor
  • BTX-B
antidystonic agents
Thuốc Gốc
Biotech
CAS: 93384-44-2
ĐG : Solstice Neurosciences , http://www.solsticeneuro.com
PTK: 150804.0000
Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Phân tử khối
150804.0000
Dược Lực Học : Botulinum Toxin Type B inhibits acetylcholine release at the neuromuscular junction via a three stage process: 1) Heavy Chain mediated neurospecific binding of the toxin, 2) internalization of the toxin by receptor-mediated endocytosis, and 3) ATP and pH dependent translocation of the Light Chain to the neuronal cytosol where it acts as a zinc-dependent endoprotease cleaving polypeptides essential for neurotransmitter release.
Cơ Chế Tác Dụng : Neurotoxin produced by fermentation of clostridium botulinum type B. The protein exists in noncovalent association with hemagglutinin and nonhemagglutinin proteins as a neurotoxin complex. The neurotoxin complex is recovered from the fermentation process and purified through a series of precipitation and chromatography steps. Botulinum Toxin Type B binds to and cleaves the synaptic Vesicle Associated Membrane Protein (VAMP, also known as synaptobrevin) which is a component of the protein complex responsible for docking and fusion of the synaptic vesicle to the presynaptic membrane, a necessary step to neurotransmitter release.
Dược Động Học :
▧ Absorption :
Though pharmacokinetic or ADME studies were not performed, Botulinum Toxin Type B is not expected to be present in the peripheral blood at measurable levels following IM injection at the recommended doses.
Độc Tính : One unit of Botulinum Toxin Type B corresponds to the calculated median lethal intraperitoneal dose (LD50) in mice.
Chỉ Định : For the treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia.
Liều Lượng & Cách Dùng : Injection, solution - Intramuscular
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00042
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D02735
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/M81186
PharmGKB
http://www.pharmgkb.org/drug/PA164747061
Wikipedia
http://en.wikipedia.org/wiki/Botulinum_toxin
RxList
http://www.rxlist.com/cgi/generic/botulinumtoxin.htm
Drugs.com
http://www.drugs.com/cdi/botulinum-toxin-type-b.html
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