Tìm theo
Botulinum Toxin Type A
Các tên gọi khác (4 ) :
  • BoNT/A
  • Bontoxilysin A
  • Botulinum neurotoxin type A precursor
  • BTX-A
neuromuscular blocking agents, anti wrinkle agents, antidystonic agents
Thuốc Gốc
Biotech
CAS: 93384-43-1
ATC: M03AX01
ĐG : Allergan Inc. , http://www.allergan.com
CTHH: C6760H10447N1743O2010S32
PTK: 149322.7000
Purified botulinum toxin from Clostridium botulinum, purified from culture via dialysis and acid precipitation.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C6760H10447N1743O2010S32
Phân tử khối
149322.7000
Độ hòa tan
Soluble
Độ kỵ nước
-0.368
Điểm đẳng điện tích
6.06
Dược Lực Học : A 150 kDa neurotoxic protein produced from fermentation of Hall strain Clostridium botulinum type A grown in a medium containing casein hydrolysate, glucose and yeast extract. It is purified from the culture solution by dialysis and a series of acid precipitations to a complex consisting of the neurotoxin, and several accessory proteins. Botulinum Toxin Type A is not expected to be present in the peripheral blood at measurable levels following IM or intradermal injection at the recommended doses. The recommended quantities of neurotoxin administered at each treatment session are not expected to result in systemic, overt distant clinical effects, i.e. muscle weakness, in patients without other neuromuscular dysfunction. However, sub-clinical systemic effects have been shown by single-fiber electromyography after IM doses of botulinum toxins appropriate to produce clinically observable local muscle weakness.
Cơ Chế Tác Dụng : Purified botulinum toxin from Clostridium botulinum, purified from culture via dialysis and acid precipitation. Botulinum Toxin Type A blocks neuromuscular transmission by binding to acceptor sites on motor or sympathetic nerve terminals, entering the nerve terminals, and inhibiting the release of acetylcholine. This inhibition occurs as the neurotoxin cleaves SNAP-25, a protein integral to the successful docking and release of acetylcholine from vesicles situated within nerve endings.
Dược Động Học :
▧ Absorption :
The chemical complexity of Botulinum Toxin Type A combined with its extreme potency limits the opportunity to study its pharmacokinetic profile in humans. Therefore, no human pharmacokinetic studies have been performed. Botulinum Toxin Type A is injected directly into the target organ, a skeletal muscle. Thus, bioavailability of the intravenous or oral route is not of clinical relevance.
Độc Tính : Based on toxicological studies, it has been estimated that the human LD50 by injection is approximately 2800 Units, equivalent to 28 individual vials of BOTOX (Botulinum Toxin Type A) Purified Neurotoxin Complex (100 Units) for a 70 kg adult. When injected intramuscularly, Botulinum Toxin Type A has been shown to be teratogenic or to have embryocidal effects in some animal species.
Chỉ Định : For the treatment of cervical dystonia in adults to decrease the severity of abnormal head position and neck pain associated with cervical dystonia. Also for the treatment of severe primary axillary hyperhidrosis that is inadequately managed with topical agents and for the treatment of strabismus and blepharospasm associated with dystonia, including benign essential blepharospasm or VII nerve disorders in patients 12 years of age and above. Also used cosmetically to temporarily improve the appearance of moderate-to-severe frown lines between the eyebrows (glabellar lines) as well as for the treatment of excessive underarm sweating.
Liều Lượng & Cách Dùng : Powder, for solution - Intramuscular
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Allegran Inc
    Sản phẩm biệt dược : Botox
  • Công ty : Allegran Inc
    Sản phẩm biệt dược : BOTOX Cosmetic
  • Công ty :
    Sản phẩm biệt dược : Dysport
  • Công ty :
    Sản phẩm biệt dược : Xeomin
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00083
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C07946
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00783
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/99207-500-30
GenBank
http://www.ncbi.nlm.nih.gov/nuccore/X52066
PharmGKB
http://www.pharmgkb.org/drug/PA164754825
Wikipedia
http://en.wikipedia.org/wiki/Botox
RxList
http://www.rxlist.com/cgi/generic/botox.htm
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