Tìm theo
Bopindolol
Các tên gọi khác (1) :
  • Sandonorm
Thuốc Gốc
Small Molecule
CAS: 69010-88-4
CTHH: C23H28N2O3
PTK: 380.48
Bopindolol (INN) is a beta blocker. It is an ester which acts as a prodrug for "pindolol":http://drugbank.ca/drugs/DB00960.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C23H28N2O3
Phân tử khối
380.48
Monoisotopic mass
380.209992772
InChI
InChI=1S/C23H28N2O3/c1-16-13-19-20(25-16)11-8-12-21(19)27-15-18(14-24-23(2,3)4)28-22(26)17-9-6-5-7-10-17/h5-13,18,24-25H,14-15H2,1-4H3
InChI Key
InChIKey=UUOJIACWOAYWEZ-UHFFFAOYSA-N
IUPAC Name
1-(tert-butylamino)-3-[(2-methyl-1H-indol-4-yl)oxy]propan-2-yl benzoate
Traditional IUPAC Name
bopindolol
SMILES
CC1=CC2=C(N1)C=CC=C2OCC(CNC(C)(C)C)OC(=O)C1=CC=CC=C1
Độ tan chảy
152–153 [malonate salt]
Độ hòa tan
3.3 mg/ml (malonate salt)
logP
4.67
logS
-5.4
pKa (strongest acidic)
16.8
pKa (Strongest Basic)
9.29
PSA
63.35 Å2
Refractivity
111.07 m3·mol-1
Polarizability
43.08 Å3
Rotatable Bond Count
9
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
3
Bioavailability
1
Rule of Five
true
Ghose Filter
true
MDDR-Like Rule
true
Dược Lực Học : Bopindolol is a prodrug of pindolol. Pindolol is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges but does not possess quinidine-like membrane stabilizing activity. Pindolol impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Pindolol is nonpolar and hydrophobic, with low to moderate lipid solubility. Pindolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, pindolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.
Cơ Chế Tác Dụng : Bopindolol (INN) is a beta blocker. It is an ester which acts as a prodrug for "pindolol":http://drugbank.ca/drugs/DB00960. Bopindolol (as pindolol) non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. By binding beta-2 receptors in the juxtaglomerular apparatus, Pindolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.
Chỉ Định : For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Sandonorm
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB08807
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D07537
ChemSpider
http://www.chemspider.com/Chemical-Structure.40146.html
PharmGKB
http://www.pharmgkb.org/drug/PA165958425
Wikipedia
http://en.wikipedia.org/wiki/Bopindolol
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