Tìm theo
Bitolterol
Các tên gọi khác (2) :
  • Bitolterol Mesylate
  • Bitolterolum
adrenergic beta 2 receptor agonists, bronchodilator agents
Thuốc Gốc
Small Molecule
CAS: 30392-40-6
ATC: R03AC17
ĐG : Pharmedix , http://www.pharmedixrx.com
CTHH: C28H31NO5
PTK: 461.5494
Bitolterol mesylate is a beta-2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD. Bitolterol was withdrawn from the market by Elan Pharmaceuticals in 2001. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C28H31NO5
Phân tử khối
461.5494
Monoisotopic mass
461.220223107
InChI
InChI=1S/C28H31NO5/c1-18-6-10-20(11-7-18)26(31)33-24-15-14-22(23(30)17-29-28(3,4)5)16-25(24)34-27(32)21-12-8-19(2)9-13-21/h6-16,23,29-30H,17H2,1-5H3
InChI Key
InChIKey=FZGVEKPRDOIXJY-UHFFFAOYSA-N
IUPAC Name
5-[2-(tert-butylamino)-1-hydroxyethyl]-2-[(4-methylphenyl)carbonyloxy]phenyl 4-methylbenzoate
Traditional IUPAC Name
5-[2-(tert-butylamino)-1-hydroxyethyl]-2-[(4-methylphenyl)carbonyloxy]phenyl 4-methylbenzoate
SMILES
CC1=CC=C(C=C1)C(=O)OC1=C(OC(=O)C2=CC=C(C)C=C2)C=C(C=C1)C(O)CNC(C)(C)C
Độ hòa tan
4.80e-04 g/l
logP
5.8
logS
-6
pKa (strongest acidic)
14
pKa (Strongest Basic)
9.59
PSA
84.86 Å2
Refractivity
132.76 m3·mol-1
Polarizability
50.91 Å3
Rotatable Bond Count
10
H Bond Acceptor Count
4
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
3
Bioavailability
1
MDDR-Like Rule
true
Dược Lực Học : Bitolterol, an adrenergic bronchodilator, is a prodrug that widens constricted airways in the lungs by relaxing the smooth muscles that surround the bronchial passages. Bitolterol probably does not affect the inflammation in the lung, such as in bronchitis. Bitolterol is unique in that it is a prodrug because it must first be metabolized by the body before it becomes active.
Cơ Chế Tác Dụng : Bitolterol mesylate is a beta-2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD. Bitolterol was withdrawn from the market by Elan Pharmaceuticals in 2001. [Wikipedia] Bitolterol is an adrenergic beta-2 agonist. Asthma results from a narrowing of the bronchial tubes. This narrowing is caused by muscle spasm and inflammation within the bronchial tubes. Agonism of the beta-2 adrenergic receptors by bitolterol leads to a relaxation of the smooth muscles surrounding these airway tubes which then increases the diameter and ease of air flow through the tubes.
Chỉ Định : Used to dilate air passages in the lungs that have become narrowed as a result of disease or inflammation. It is used in the treatment of asthma and chronic obstructive pulmonary disease (COPD).
Tương Tác Thuốc :
  • Entacapone Entacapone may increase the effect and toxicity of bitolterol.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Tornalate
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00901
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=35330
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506895
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06853
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00684
ChemSpider
http://www.chemspider.com/Chemical-Structure.32525.html
PharmGKB
http://www.pharmgkb.org/drug/PA448644
Wikipedia
http://en.wikipedia.org/wiki/Bitolterol
Drugs.com
http://www.drugs.com/mtm/bitolterol-inhalation.html
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