Tìm theo
Biotin
Các tên gọi khác (16 ) :
  • (+)-cis-Hexahydro-2-oxo-1H-thieno[3,4]imidazole-4-valeric acid
  • (3AS,4S,6ar)-hexahydro-2-oxo-1H-thieno[3,4-D]imidazole-4-valeric acid
  • 5-(2-Oxohexahydro-1H-thieno[3,4-D]imidazol-4-yl)pentanoic acid
  • Biotin
  • Biotina
  • Biotine
  • Biotinum
  • cis-(+)-Tetrahydro-2-oxothieno[3,4]imidazoline-4-valeric acid
  • cis-Hexahydro-2-oxo-1H-thieno(3,4)imidazole-4-valeric acid
  • cis-Tetrahydro-2-oxothieno(3,4-D)imidazoline-4-valeric acid
  • Coenzyme R
  • D-(+)-Biotin
  • D-Biotin
  • D(+)-Biotin
  • Vitamin B7
  • Vitamin H
Khoáng chất và Vitamin
Thuốc Gốc
Small Molecule
CAS: 58-85-5
ATC: A11HA05
ĐG : 21st Century Healthcare Inc. , http://www.21stcenturyvitamins.com
CTHH: C10H16N2O3S
PTK: 244.311
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H16N2O3S
Phân tử khối
244.311
Monoisotopic mass
244.088163078
InChI
InChI=1S/C10H16N2O3S/c13-8(14)4-2-1-3-7-9-6(5-16-7)11-10(15)12-9/h6-7,9H,1-5H2,(H,13,14)(H2,11,12,15)/t6-,7-,9-/m0/s1
InChI Key
InChIKey=YBJHBAHKTGYVGT-ZKWXMUAHSA-N
IUPAC Name
5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanoic acid
Traditional IUPAC Name
biotin
SMILES
[H][C@]12CS[C@@H](CCCCC(O)=O)[C@@]1([H])NC(=O)N2
Độ tan chảy
232 dec °C
Độ hòa tan
220 mg/L (at 25 °C)
logP
0.5
logS
-2.3
pKa (strongest acidic)
4.4
pKa (Strongest Basic)
-1.9
PSA
78.43 Å2
Refractivity
60.05 m3·mol-1
Polarizability
24.92 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
3
H Bond Donor Count
3
Physiological Charge
-1
Number of Rings
2
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Biotin is a water-soluble B-complex vitamin which is composed of an ureido ring fused with a tetrahydrothiophene ring. A valeric acid substituent is attached to one of the carbon atoms of the tetrahydrothiophene ring. Biotin is used in cell growth, the production of fatty acids, metabolism of fats, and amino acids. It plays a role in the Kreb cycle, which is the process in which energy is released from food. Biotin not only assists in various metabolic chemical conversions, but also helps with the transfer of carbon dioxide. Biotin is also helpful in maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails. Consequenty, it is found in many cosmetic and health products for the hair and skin. Biotin deficiency is a rare nutritional disorder caused by a deficiency of biotin. Initial symptoms of biotin deficiency include: Dry skin, Seborrheic dermatitis, Fungal infections, rashes including erythematous periorofacial macular rash, fine and brittle hair, and hair loss or total alopecia. If left untreated, neurological symptoms can develop, including mild depression, which may progress to profound lassitude and, eventually, to somnolence; changes in mental status, generalized muscular pains (myalgias), hyperesthesias and paresthesias. The treatment for biotin deficiency is to simply start taking some biotin supplements. A lack of biotin in infants will lead to a condition called seborrheic dermatitis or "cradle cap". Biotin deficiencies are extremely rare in adults but if it does occur, it will lead to anemia, depression, hair loss, high blood sugar levels, muscle pain, nausea, loss of appetite and inflamed mucous membranes.
Cơ Chế Tác Dụng : A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. [PubChem] Biotin is necessary for the proper functioning of enzymes that transport carboxyl units and fix carbon dioxide, and is required for various metabolic functions, including gluconeogenesis, lipogenesis, fatty acid biosynthesis, propionate metabolism, and catabolism of branched-chain amino acids.
Dược Động Học :
▧ Absorption :
Systemic - approximately 50%
Độc Tính : Prolonged skin contact may cause irritation.
Chỉ Định : For nutritional supplementation, also for treating dietary shortage or imbalance.
Liều Lượng & Cách Dùng : Powder, for solution - Oral
Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : D-biotin powder
    Giá bán buôn : USD >12.0
    Đơn vị tính : g
  • Biệt dược thương mại : Biotin powder
    Giá bán buôn : USD >14.69
    Đơn vị tính : g
  • Biệt dược thương mại : Biotin 300 mcg tablet
    Giá bán buôn : USD >0.03
    Đơn vị tính : tablet
  • Biệt dược thương mại : Biotin 800 mcg tablet
    Giá bán buôn : USD >0.06
    Đơn vị tính : tablet
  • Biệt dược thương mại : Stress 600 tablet
    Giá bán buôn : USD >0.08
    Đơn vị tính : tablet
  • Biệt dược thương mại : Stress b tablet
    Giá bán buôn : USD >0.1
    Đơn vị tính : tablet
  • Biệt dược thương mại : Appearex 2.5 mg tablet
    Giá bán buôn : USD >0.26
    Đơn vị tính : tablet
  • Biệt dược thương mại : Diachrome capsule
    Giá bán buôn : USD >0.29
    Đơn vị tính : capsule
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Appearex
  • Công ty :
    Sản phẩm biệt dược : Biodermatin
  • Công ty :
    Sản phẩm biệt dược : Biotin Forte
  • Công ty :
    Sản phẩm biệt dược : Meribin
  • Công ty :
    Sản phẩm biệt dược : Nail-ex
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00121
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=171548
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508694
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C00120
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D00029
ChemSpider
http://www.chemspider.com/Chemical-Structure.149962.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=12
PharmGKB
http://www.pharmgkb.org/drug/PA448625
Wikipedia
http://en.wikipedia.org/wiki/Biotin
PDRhealth
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/bio_0035.shtml
Drugs.com
http://www.drugs.com/cons/biotin.html
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