Tìm theo
Binodenoson
Các tên gọi khác (2) :
  • 2-((Cyclohexylmethylene)hydrazino)adenosine
  • MRE 0470
diagnostic agents
Thuốc Gốc
Small Molecule
CAS: 144348-08-3
CTHH: C17H25N7O4
PTK: 391.4249
Binodenoson is a pharmacologic stress agent specific to the only adenosine receptor necessary for increased cardiac blood flow, the A2A receptor. This specificity allows Binodenoson to deliver - in a single injection - a more effective dose of medication with fewer side effects than current treatments, which typically require a 15-20 minute infusion.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C17H25N7O4
Phân tử khối
391.4249
Monoisotopic mass
391.196802323
InChI
InChI=1S/C17H25N7O4/c18-14-11-15(22-17(21-14)23-20-6-9-4-2-1-3-5-9)24(8-19-11)16-13(27)12(26)10(7-25)28-16/h6,8-10,12-13,16,25-27H,1-5,7H2,(H3,18,21,22,23)/b20-6+/t10-,12-,13-,16-/m1/s1
InChI Key
InChIKey=XJFMHMFFBSOEPR-DNZQAUTHSA-N
IUPAC Name
(2R,3R,4S,5R)-2-{6-amino-2-[(E)-2-(cyclohexylmethylidene)hydrazin-1-yl]-9H-purin-9-yl}-5-(hydroxymethyl)oxolane-3,4-diol
Traditional IUPAC Name
(2R,3R,4S,5R)-2-{6-amino-2-[(E)-2-(cyclohexylmethylidene)hydrazin-1-yl]purin-9-yl}-5-(hydroxymethyl)oxolane-3,4-diol
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=C(N\N=C\C3CCCCC3)N=C12
Độ hòa tan
1.14e+00 g/l
logP
0.46
logS
-2.5
pKa (strongest acidic)
10.99
pKa (Strongest Basic)
4.34
PSA
163.93 Å2
Refractivity
101.74 m3·mol-1
Polarizability
40.99 Å3
Rotatable Bond Count
5
H Bond Acceptor Count
10
H Bond Donor Count
5
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Binodenoson, a novel cardiovascular disease diagnostic, is a adenosine A2A receptor agonist in development for cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease.
Cơ Chế Tác Dụng : Binodenoson is a pharmacologic stress agent specific to the only adenosine receptor necessary for increased cardiac blood flow, the A2A receptor. This specificity allows Binodenoson to deliver - in a single injection - a more effective dose of medication with fewer side effects than current treatments, which typically require a 15-20 minute infusion. Binodenoson is a highly selective adenosine A2A receptor agonist. The adenosine A2A receptor is necessary for increased cardiac blood flow, and specificity to this particular receptor allows binodenoson to deliver, in a single injection, a more effective dose of medication with fewer side effects than current treatments, which typically require a 15-20 minute infusion. Cardiac stress tests allow physicians to identify the presence of cardiovascular disease by examining the flow of blood through the heart.
Dược Động Học :

▧ Half Life :
10 ± 4 minutes
Chỉ Định : For cardiac pharmacologic stress SPECT imaging, which is used to diagnose coronary artery disease.
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04853
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=9576912
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=11968305
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D03120
ChemSpider
http://www.chemspider.com/Chemical-Structure.7851353.html
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