Tìm theo
Bifonazole
Các tên gọi khác (10 ) :
  • (+-)-1-(p,alpha-Diphenylbenzyl)imidazole
  • (+-)1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole
  • 1-((4-Biphenylyl)phenylmethyl)-1H-imidazole
  • 1-(alpha-(4-Biphenylyl)benzyl)imidazole
  • 1-(p,alpha-Diphenylbenzyl)imidazole
  • Bay h 4502
  • Bifonazol
  • Bifonazolum
  • Mycospor
  • Trifonazole
antifungal agents
Thuốc Gốc
Small Molecule
CAS: 60628-96-8
CTHH: C22H18N2
PTK: 310.3917
Bifonazole is an azole antifungal drug. [Wikipedia]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C22H18N2
Phân tử khối
310.3917
Monoisotopic mass
310.146998586
InChI
InChI=1S/C22H18N2/c1-3-7-18(8-4-1)19-11-13-21(14-12-19)22(24-16-15-23-17-24)20-9-5-2-6-10-20/h1-17,22H
InChI Key
InChIKey=OCAPBUJLXMYKEJ-UHFFFAOYSA-N
IUPAC Name
1-[phenyl(4-phenylphenyl)methyl]-1H-imidazole
Traditional IUPAC Name
bifonazole
SMILES
C1=CN(C=N1)C(C1=CC=CC=C1)C1=CC=C(C=C1)C1=CC=CC=C1
Độ tan chảy
142
Độ hòa tan
2.45e-03 g/l
logP
4.77
logS
-5.1
pKa (Strongest Basic)
6.69
PSA
17.82 Å2
Refractivity
97.94 m3·mol-1
Polarizability
35.41 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
1
H Bond Donor Count
0
Physiological Charge
0
Number of Rings
4
Bioavailability
1
Ghose Filter
true
Dược Lực Học : Bifonazole is a type of antifungal medicine known as an imidazole. It kills fungi and yeasts by interfering with their cell membranes.
Cơ Chế Tác Dụng : Bifonazole is an azole antifungal drug. [Wikipedia] Bifonazole works by inhibiting the production of a substance called ergosterol, which is an essential component of fungal cell membranes.It acts to destabilize the fungal cyctochrome p450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. The disruption in production of ergosterol disrupts the cell membrane and causes holes to appear. The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As bifonazole causes holes to appear in the cell membranes, essential constituents of the fungal cells can leak out. This kills the fungi.
Dược Động Học :
▧ Absorption :
Very low absorption following topical administration (0.6% of an applied dose). In cases of skin lesions absorption is increased (2.5%).
▧ Metabolism :
Hepatic.
▧ Half Life :
1-2 hours
Chỉ Định : Used for the treatment of various topical fungal infections, including athlete's foot (tinea pedis).
Liều Lượng & Cách Dùng : Cream - Topical
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty : Merck
    Sản phẩm biệt dược : Amycor
  • Công ty : Menarini
    Sản phẩm biệt dược : Azolmen
  • Công ty : Bayer
    Sản phẩm biệt dược : Bayclear Plus
  • Công ty : Mayado Seiyaku
    Sản phẩm biệt dược : Bifonol
  • Công ty : Bayer
    Sản phẩm biệt dược : Canespor
  • Công ty : Bayer
    Sản phẩm biệt dược : Canesten
  • Công ty : Bayer
    Sản phẩm biệt dược : Mycospor
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB04794
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2378
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507284
ChemSpider
http://www.chemspider.com/Chemical-Structure.2287.html
BindingDB
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50128548
PharmGKB
http://www.pharmgkb.org/drug/PA164746464
Wikipedia
http://en.wikipedia.org/wiki/Bifonazole
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