Tìm theo
Bethanidine
Các tên gọi khác (4 ) :
  • Betanidina
  • Betanidine
  • Betanidinum
  • N,N'-dimethyl-N''-(phenylmethyl)-guanidine
antihypertensive agents, adrenergic agents, sympatholytics
Thuốc Gốc
Small Molecule
CAS: 55-73-2
ATC: C02CC01
CTHH: C10H15N3
PTK: 177.2462
A guanidinium antihypertensive agent that acts by blocking adrenergic transmission.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C10H15N3
Phân tử khối
177.2462
Monoisotopic mass
177.126597495
InChI
InChI=1S/C10H15N3/c1-11-10(12-2)13-8-9-6-4-3-5-7-9/h3-7H,8H2,1-2H3,(H2,11,12,13)
InChI Key
InChIKey=NIVZHWNOUVJHKV-UHFFFAOYSA-N
IUPAC Name
(E)-3-benzyl-1,2-dimethylguanidine
Traditional IUPAC Name
bethanidine
SMILES
CN\C(NCC1=CC=CC=C1)=N/C
Độ tan chảy
196 °C
Độ hòa tan
1.58e+00 g/l
logP
0.49
logS
-2
pKa (Strongest Basic)
12.41
PSA
36.42 Å2
Refractivity
54.5 m3·mol-1
Polarizability
20.43 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
3
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Ghose Filter
true
Dược Lực Học : Bethanidine is a guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear. Although bethanidine may produce adverse effects, they are beneficial in severe hypertension and produce fewer side effects than guanethidine.
Cơ Chế Tác Dụng : A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. Bethanidine, a guanidine derivative, is a peripherally acting antiadrenergic agent which primarily acts as an alpha2a adrenergic agonist. Bethanidine effectively decreases blood pressure by suppressing renin secretion or interfering with function of the sympathetic nervous system.
Dược Động Học :
▧ Absorption :
Absorbed rapidly in the gastrointestinal tract following oral administration.
▧ Half Life :
9 hours (range 7 to 11 hours)
Chỉ Định : For the treatment of hypertension.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Esbatal
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00217
KEGG Drug
http://www.genome.jp/dbget-bin/www_bget?drug:D01603
PharmGKB
http://www.pharmgkb.org/drug/PA164743235
... loading
... loading