Tìm theo
Bethanechol
Các tên gọi khác (9 ) :
  • (2-Hydroxypropyl)trimethylammonium carbamate
  • 2-(Carbamoyloxy)-N,N,N-trimethylpropan-1-aminium
  • 2-Carbamoyloxypropyl-trimethylazanium
  • Amidopropyldimethylbetaine
  • Bethanechol
  • Carbamoyl-beta-methylcholine
  • carbamoyl-β-methylcholine
  • Carbamyl-beta-methylcholine
  • carbamyl-β-methylcholine
parasympathomimetics, muscarinic agonists
Thuốc Gốc
Small Molecule
CAS: 674-38-4
ATC: N07AB02
ĐG : Actavis Group , http://www.actavis.com
CTHH: C7H17N2O2
PTK: 161.2221
Bethanechol is a synthetic ester structurally and pharmacologically related to acetylcholine. A slowly hydrolyzed muscarinic agonist with no nicotinic effects, bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C7H17N2O2
Phân tử khối
161.2221
Monoisotopic mass
161.129002798
InChI
InChI=1S/C7H16N2O2/c1-6(11-7(8)10)5-9(2,3)4/h6H,5H2,1-4H3,(H-,8,10)/p+1
InChI Key
InChIKey=NZUPCNDJBJXXRF-UHFFFAOYSA-O
IUPAC Name
1-(trimethylazaniumyl)propan-2-yl carbamate
Traditional IUPAC Name
bethanechol
SMILES
CC(C[N+](C)(C)C)OC(N)=O
Độ tan chảy
about 220
Độ hòa tan
10 mg/mL (chloride salt)
logP
-4.1
logS
-2.8
pKa (strongest acidic)
15.34
PSA
52.32 Å2
Refractivity
54.44 m3·mol-1
Polarizability
17.73 Å3
Rotatable Bond Count
4
H Bond Acceptor Count
1
H Bond Donor Count
1
Physiological Charge
1
Number of Rings
0
Bioavailability
1
Rule of Five
true
Dược Lực Học : Bethanechol is a parasympathomimetic (cholinergic) used for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Bethanechol, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores impaired rhythmic peristalsis. Bethanechol chloride is not destroyed by cholinesterase and its effects are more prolonged than those of acetytcholine.
Cơ Chế Tác Dụng : Bethanechol is a synthetic ester structurally and pharmacologically related to acetylcholine. A slowly hydrolyzed muscarinic agonist with no nicotinic effects, bethanechol is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms. [PubChem] Bethanechol directly stimulates cholinergic receptors in the parasympathetic nervous system while stimulating the ganglia to a lesser extent. Its effects are predominantly muscarinic, inducing little effect on nicotinic receptors and negligible effects on the cardiovascular system.
Chỉ Định : For the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention.
Tương Tác Thuốc :
  • Tacrine The acetylcholinesterase inhibitor, Tacrine, may increase the cholinergic effects of Bethanecol, a cholinergic agonist. Monitor for increased cholinergic effects.
Liều Lượng & Cách Dùng : Tablet - Oral
Dữ Kiện Thương Mại
Giá thị trường
Nhà Sản Xuất
  • Công ty : Roberts
    Sản phẩm biệt dược : Duvoid
  • Công ty : Glenwood
    Sản phẩm biệt dược : Myotonachol
  • Công ty :
    Sản phẩm biệt dược : Myotonine
  • Công ty :
    Sản phẩm biệt dược : Urabeth
  • Công ty : Merck Frosst
    Sản phẩm biệt dược : Urecholine
  • Công ty : Hamilton
    Sản phẩm biệt dược : Uro-Carb
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB01019
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=2370
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507707
KEGG Compound
http://www.genome.jp/dbget-bin/www_bget?cpd:C06850
ChemSpider
http://www.chemspider.com/Chemical-Structure.2280.html
National Drug Code Directory
http://www.hipaaspace.com/Medical_Billing/Coding/National.Drug.Codes/PDF/0527-1332-01
PharmGKB
http://www.pharmgkb.org/drug/PA448613
Wikipedia
http://en.wikipedia.org/wiki/Bethanechol
RxList
http://www.rxlist.com/cgi/generic3/bethane.htm
Drugs.com
http://www.drugs.com/cdi/bethanechol.html
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