Tìm theo
Betazole
Các tên gọi khác (9 ) :
  • 1H-pyrazole-3-ethanamine
  • 2-(1H-Pyrazol-5-yl)ethanamine
  • 2-(3-Pyrazolyl)ethylamine
  • 3-(2-Aminoethyl)pyrazole
  • 3-(beta-aminoethyl)pyrazole
  • 3-(β-aminoethyl)pyrazole
  • Ametazole
  • Betazol
  • Betazolum
gastrointestinal agents, histamine agonists, diagnostic agents
Thuốc Gốc
Small Molecule
CAS: 105-20-4
ATC: V04CG02
CTHH: C5H9N3
PTK: 111.1451
A histamine H2 agonist used clinically to test gastric secretory function. [PubChem]
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C5H9N3
Phân tử khối
111.1451
Monoisotopic mass
111.079647303
InChI
InChI=1S/C5H9N3/c6-3-1-5-2-4-7-8-5/h2,4H,1,3,6H2,(H,7,8)
InChI Key
InChIKey=JXDFEQONERDKSS-UHFFFAOYSA-N
IUPAC Name
2-(1H-pyrazol-5-yl)ethan-1-amine
Traditional IUPAC Name
betazole
SMILES
NCCC1=CC=NN1
Độ tan chảy
< 25 °C
Độ sôi
118-123
Độ hòa tan
1.56e+02 g/l
logP
0.1
logS
0.15
pKa (strongest acidic)
14.52
pKa (Strongest Basic)
9.79
PSA
54.7 Å2
Refractivity
32.96 m3·mol-1
Polarizability
11.96 Å3
Rotatable Bond Count
2
H Bond Acceptor Count
2
H Bond Donor Count
2
Physiological Charge
1
Number of Rings
1
Bioavailability
1
Rule of Five
true
Dược Lực Học : Betazole is a histamine H2 agonist used in a test for measuring maximal production of gastric acidity or anacidity. This measurement can be used to diagnose diseases such as Zollinger-Ellison syndrome, whereby the volume of gastric and basal secretions is measured following betazole administration (greater than 60% of the maximal acid secretion following betazole stimulation). In another test, gastritis can be diagnosed given late absence of gastric acid which is unresponsive to betazole stimulation. Betazole can be used as a gastric secretory stimulant instead of histamine with the advantage of not provoking side effects and thus not requiring the use of antihistaminic compounds.
Cơ Chế Tác Dụng : A histamine H2 agonist used clinically to test gastric secretory function. [PubChem] Betazole is a histamine analogue. It produces the same effects as histamine, binding the H2 receptor which is a mediator of gastric acid secretion. This agonist action thereby results in an increase in the volume of gastric acid produced.
Dược Động Học :
▧ Absorption :
Rapid and complete.
▧ Protein binding :
> 99%
Chỉ Định : For use clinically to test gastric secretory function.
Dữ Kiện Thương Mại
Nhà Sản Xuất
  • Công ty :
    Sản phẩm biệt dược : Gastramine
  • Công ty : Lilly
    Sản phẩm biệt dược : Histalog
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00272
PubChem Compound
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7741
PubChem Substance
http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506808
ChemSpider
http://www.chemspider.com/Chemical-Structure.7455.html
PharmGKB
http://www.pharmgkb.org/drug/PA164784036
Wikipedia
http://en.wikipedia.org/wiki/Betazole
... loading
... loading