Tìm theo
Benzylpenicilloyl Polylysine
Các tên gọi khác (4 ) :
  • benzylpenicilloyl G polylysine
  • Benzylpenicilloyl-polylysine
  • Penicilloyl polylysine
  • Penicilloyl-polylysine
Thuốc Gốc
Small Molecule
CAS: 2642-55-9
ĐG : Allerquest LLC , http://www.allerquest.com
CTHH: C28H46N6O8S
PTK: 626.765
Benzylpenicilloyl Polylysine is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluating allergic subjects.
Nhận Dạng Quốc Tế & Đặc Tính Hóa Học
Công thức hóa học
C28H46N6O8S
Phân tử khối
626.765
Monoisotopic mass
626.309783168
InChI
InChI=1S/C22H32N4O6S.C6H14N2O2/c1-22(2)17(21(31)32)26-19(33-22)16(25-15(27)12-13-8-4-3-5-9-13)18(28)24-11-7-6-10-14(23)20(29)30;7-4-2-1-3-5(8)6(9)10/h3-5,8-9,14,16-17,19,26H,6-7,10-12,23H2,1-2H3,(H,24,28)(H,25,27)(H,29,30)(H,31,32);5H,1-4,7-8H2,(H,9,10)/t14-,16?,17+,19-;5-/m11/s1
InChI Key
InChIKey=IMPVZRLKKKXMKQ-SGDOCVTFSA-N
logP
-0.8
PSA
170.85 Å2
Refractivity
122.22 m3·mol-1
Polarizability
50.05 Å3
Rotatable Bond Count
17
H Bond Acceptor Count
8
H Bond Donor Count
6
Dược Lực Học : Benylpenicilloyl polylysine is penicilloyl bound to polylysine and is considered to be the major determinant of penicillin metabolism; it is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. If skin testing using benzylpenicilloyl and penicillin G (as the sole source of minor determinants) is negative, approximately 97% of patients with a negative skin test will tolerate penicillin.
Cơ Chế Tác Dụng : Benzylpenicilloyl Polylysine is used as a skin-testing reagent to detect immunoglobulin E antibodies in people with a history of penicillin allergy. The quantitation of in vitro IgE antibodies to the benzylpenicilloyl determinant is a useful tool for evaluating allergic subjects. The skin test for penicillin demonstrates the presence or absence of specific IgE antibodies to major and minor penicillin determinants. IgE antibodies to major determinants can be detected by using benzylpenicilloyl polylysine. A penicillin skin test predicts only the presence of IgE antibodies for the major or minor penicillin determinants at the time of application and does not predict the future development of IgE-mediated reactions during subsequent courses of penicillin. Benzylpenicilloyl polylysine reacts specifically with penicilloyl skin sensitizing antibodies (reagins) to produce immediate wheal and flare reactions which may reflect increased risk of allergic reactions to subsequent penicillin therapy.
Độc Tính : Symptoms of overdose include urticaria, generalized pruritus, local swelling, generalized flushing, anaphylaxis, bronchospasm, fainting and maculopapular eruption.
Chỉ Định : For use as a adjunct in assessing the risk of administering penicillin (benzylpenicillin or penicillin G).
Tương Tác Thuốc :
  • Carbinoxamine Antihistamines may diminish the diagnostic effect of Benzylpenicilloyl Polylysine. Treatment with systemic histamine H1 antagonists such as carbinoxamine should be suspended for benzylpenicilloyl-polylysine skin testing to minimize the potential for false negative results. Delay skin testing until the systemic effects of the antihistamine have dissipated. A histamine skin test may be used to assess residual antihistaminic effects.
Liều Lượng & Cách Dùng : Liquid - Intradermal
Dữ Kiện Thương Mại
Giá thị trường
  • Biệt dược thương mại : Pre-pen ampul
    Giá bán buôn : USD >72.0
    Đơn vị tính : ampul
Nhà Sản Xuất
Đóng gói
Tài Liệu Tham Khảo Thêm
drugbank
http://www.drugbank.ca/drugs/DB00895
PharmGKB
http://www.pharmgkb.org/drug/PA164754810
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